| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. SUBUNIT: Self-associates (By similarity). Interacts with ORC2. May interact with MCM2 and MCM6. Interacts with the DNA polymerase alpha subunit POLA1. Interacts with RECQL4; this interaction regulates RECQL4 unwinding activity. Interacts with WDHD1. SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q7L590-1; Sequence=Displayed; Name=2; IsoId=Q7L590-2; Sequence=VSP_029951; DEVELOPMENTAL STAGE: Expression is cell cycle regulated. Expression increases at the G1/S-boundary. Expression decreases in late M phase, remains low during G(1) phase, and starts to accumulate at the onset of S phase. DOMAIN: The zinc finger-like domain binds a zinc ion and is involved in self-association (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the MCM10 family. SEQUENCE CAUTION: Sequence=AAF69623.1; Type=Erroneous initiation; GENE SYNONYMS:MCM10. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 875 AA; 98183 MW; DD87191FFF3729D4 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:18043,
urn:biopax:RelationshipXref:NCBI GENE_55388,
urn:biopax:RelationshipXref:REFSEQ_NP_060988,
urn:biopax:RelationshipXref:REFSEQ_NP_877428,
urn:biopax:UnificationXref:UNIPROT_A8K9I6,
urn:biopax:UnificationXref:UNIPROT_B7ZKZ8,
urn:biopax:UnificationXref:UNIPROT_Q3MIR3,
urn:biopax:UnificationXref:UNIPROT_Q7L590,
urn:biopax:UnificationXref:UNIPROT_Q7LD55,
urn:biopax:UnificationXref:UNIPROT_Q96GX4,
urn:biopax:UnificationXref:UNIPROT_Q96NB6,
urn:biopax:UnificationXref:UNIPROT_Q9H0D7,
urn:biopax:UnificationXref:UNIPROT_Q9H3P9,
urn:biopax:UnificationXref:UNIPROT_Q9P177
|
| biopax3:displayName |
MCM10_HUMAN
|
| biopax3:name |
HsMCM10,
MCM10
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MDEEEDNLSLLTALLEENESALDCNSEENNFLTRENGEPDAFDELFDADGDGESYTEEADDGETGETRDEKENLATLFGDMEDLTDEEEVPASQSTENRVLPAPAPRREKTNEELQEELRNLQEQMKALQEQLKVTTIKQTASPARLQKSPVEKSPRPPLKERRVQRIQESTCFSAELDVPALPRTKRVARTPKASPPDPKSSSSRMTSAPSQPLQTISRNKPSGITRGQIVGTPGSSGETTQPICVEAFSGLRLRRPRVSSTEMNKKMTGRKLIRLSQIKEKMAREKLEEIDWVTFGVILKKVTPQSVNSGKTFSIWKLNDLRDLTQCVSLFLFGEVHKALWKTEQGTVVGILNANPMKPKDGSEEVCLSIDHPQKVLIMGEALDLGTCKAKKKNGEPCTQTVNLRDCEYCQYHVQAQYKKLSAKRADLQSTFSGGRIPKKFARRGTSLKERLCQDGFYYGGVSSASYAASIAAAVAPKKKIQTTLSNLVVKGTNLIIQETRQKLGIPQKSLSCSEEFKELMDLPTCGARNLKQHLAKATASGIMGSPKPAIKSISASALLKQQKQRMLEMRRRKSEEIQKRFLQSSSEVESPAVPSSSRQPPAQPPRTGSEFPRLEGAPATMTPKLGRGVLEGDDVLFYDESPPPRPKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERVEKNTMFSSQAEDELEPARKKRREQLAYLESEEFQKILKAKSKHTGILKEAEAEMQERYFEPLVKKEQMEEKMRNIREVKCRVVTCKTCAYTHFKLLETCVSEQHEYHWHDGVKRFFKCPCGNRSISLDRLPNKHCSNCGLYKWERDGMLKEKTGPKIGGETLLPRGEEHAKFLNSLK
|
| biopax3:standardName |
Protein MCM10 homolog
|