| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Homodimer. Interacts with MAP3K3 and promotes the kinase activity of this enzyme. SUBCELLULAR LOCATION: Cytoplasmic vesicle. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6Q0C0-1; Sequence=Displayed; Name=2; IsoId=Q6Q0C0-2; Sequence=VSP_051607; TISSUE SPECIFICITY: Ubiquitously expressed with high levels in skeletal muscle, heart, colon, spleen, kidney, liver and placenta. PTM: Phosphorylated by MAP3K3. PTM: Ubiquitinates itself upon phosphorylation. SIMILARITY: Belongs to the WD repeat TRAF7 family. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 1 TRAF-type zinc finger. SIMILARITY: Contains 7 WD repeats. GENE SYNONYMS:TRAF7 RFWD1 RNF119. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 670 AA; 74609 MW; 5624045D674849C6 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
TRAF7_HUMAN
|
| biopax3:name |
6.3.2.-,
RING finger and WD repeat-containing protein 1,
RING finger protein 119,
TNF receptor-associated factor 7,
TRAF7
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTPSSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCPPLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC
|
| biopax3:standardName |
E3 ubiquitin-protein ligase TRAF7
|