| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes (By similarity). CATALYTIC ACTIVITY: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate. COFACTOR: Manganese (By similarity). SUBUNIT: Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4 (By similarity). Interacts with AMBRA1. Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive (By similarity). Part of a complex composed of PIK3R4 and PIK3CB. Interacts with RAB7A in the presence of PIK3R4 (By similarity). SUBCELLULAR LOCATION: Midbody (By similarity). Late endosome (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6PF93-1; Sequence=Displayed; Name=2; IsoId=Q6PF93-2; Sequence=VSP_016459, VSP_016460; Note=No experimental confirmation available; SIMILARITY: Belongs to the PI3/PI4-kinase family. SIMILARITY: Contains 1 C2 PI3K-type domain. SIMILARITY: Contains 1 PI3K/PI4K domain. SIMILARITY: Contains 1 PIK helical domain. GENE SYNONYMS:Pik3c3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 887 AA; 101487 MW; 80E8EF9EF3AF74D7 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
PK3C3_MOUSE
|
| biopax3:name |
2.7.1.137,
PI3-kinase type 3,
PI3K type 3,
Phosphoinositide-3-kinase class 3,
Pik3c3,
PtdIns-3-kinase type 3
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:PK3C3_MOUSE_1,
urn:biopax:ModificationFeature:PK3C3_MOUSE_2,
urn:biopax:ModificationFeature:PK3C3_MOUSE_3,
urn:biopax:ModificationFeature:PK3C3_MOUSE_4,
urn:biopax:ModificationFeature:PK3C3_MOUSE_5,
urn:biopax:ModificationFeature:PK3C3_MOUSE_6,
urn:biopax:ModificationFeature:PK3C3_MOUSE_7,
urn:biopax:ModificationFeature:PK3C3_MOUSE_8
|
| biopax3:organism | |
| biopax3:sequence |
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGSAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQTSASESLSNSGVSSGDIDSSQIITNPLPPVASPPPASKAKEVSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPYGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK
|
| biopax3:standardName |
Phosphatidylinositol 3-kinase catalytic subunit type 3
|