| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. SUBUNIT: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6P2C8-1; Sequence=Displayed; Name=2; IsoId=Q6P2C8-2; Sequence=VSP_051869; SIMILARITY: Belongs to the Mediator complex subunit 27 family. SEQUENCE CAUTION: Sequence=AAH02878.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=AAH02878.1; Type=Erroneous termination; Positions=109; Note=Translated as Gln; Sequence=CAH72530.1; Type=Erroneous initiation; Sequence=CAH72547.1; Type=Erroneous initiation; Sequence=CAI13387.1; Type=Erroneous initiation; Sequence=CAI17284.1; Type=Erroneous initiation; GENE SYNONYMS:MED27 CRSP34 CRSP8. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 311 AA; 35432 MW; 996D675993E393CB CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:2377,
urn:biopax:RelationshipXref:NCBI GENE_9442,
urn:biopax:RelationshipXref:REFSEQ_NP_001240810,
urn:biopax:RelationshipXref:REFSEQ_NP_004260,
urn:biopax:UnificationXref:UNIPROT_O95401,
urn:biopax:UnificationXref:UNIPROT_Q4F964,
urn:biopax:UnificationXref:UNIPROT_Q5VTA4,
urn:biopax:UnificationXref:UNIPROT_Q5VTA5,
urn:biopax:UnificationXref:UNIPROT_Q6P2C8,
urn:biopax:UnificationXref:UNIPROT_Q9BU57,
urn:biopax:UnificationXref:UNIPROT_Q9NYR4
|
| biopax3:displayName |
MED27_HUMAN
|
| biopax3:name |
CRSP complex subunit 8,
Cofactor required for Sp1 transcriptional activation subunit 8,
MED27,
Mediator complex subunit 27,
P37 TRAP/SMCC/PC2 subunit,
Transcriptional coactivator CRSP34
|
| biopax3:organism | |
| biopax3:sequence |
MADVINVSVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ
|
| biopax3:standardName |
Mediator of RNA polymerase II transcription subunit 27
|