| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP. COFACTOR: FAD (By similarity). COFACTOR: NADP. SUBUNIT: Homodimer. Interacts with BNIP3L, MYT1 and TCTP. SUBCELLULAR LOCATION: Endosome membrane; Multi-pass membrane protein (By similarity). Note=Localizes to vesicular-like structures at the plasma membrane and around the nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q658P3-1; Sequence=Displayed; Name=2; IsoId=Q658P3-2; Sequence=VSP_024829; Name=3; IsoId=Q658P3-3; Sequence=VSP_024830; Name=4; Synonyms=pHyde II; IsoId=Q658P3-4; Sequence=VSP_024830, VSP_024831; TISSUE SPECIFICITY: Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma. INDUCTION: By p53/TP53. SIMILARITY: Belongs to the STEAP family. SIMILARITY: Contains 1 ferric oxidoreductase domain. CAUTION: Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033). GENE SYNONYMS:STEAP3 TSAP6. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 488 AA; 54601 MW; C89EB0D0430F9BFB CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:24592,
urn:biopax:RelationshipXref:NCBI GENE_55240,
urn:biopax:RelationshipXref:REFSEQ_NP_001008410,
urn:biopax:RelationshipXref:REFSEQ_NP_060704,
urn:biopax:RelationshipXref:REFSEQ_NP_878919,
urn:biopax:UnificationXref:UNIPROT_A8K6E3,
urn:biopax:UnificationXref:UNIPROT_Q4VBR2,
urn:biopax:UnificationXref:UNIPROT_Q4ZG36,
urn:biopax:UnificationXref:UNIPROT_Q53SQ8,
urn:biopax:UnificationXref:UNIPROT_Q658P3,
urn:biopax:UnificationXref:UNIPROT_Q7Z389,
urn:biopax:UnificationXref:UNIPROT_Q86SF6,
urn:biopax:UnificationXref:UNIPROT_Q8NEW6,
urn:biopax:UnificationXref:UNIPROT_Q8TDP3,
urn:biopax:UnificationXref:UNIPROT_Q8TF03,
urn:biopax:UnificationXref:UNIPROT_Q9NVB5
|
| biopax3:displayName |
STEA3_HUMAN
|
| biopax3:name |
1.16.1.-,
Dudulin-2,
STEAP3,
Six-transmembrane epithelial antigen of prostate 3,
Tumor suppressor-activated pathway protein 6,
hTSAP6,
hpHyde,
pHyde
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MPEEMDKPLISLHLVDSDSSLAKVPDEAPKVGILGSGDFARSLATRLVGSGFKVVVGSRNPKRTARLFPSAAQVTFQEEAVSSPEVIFVAVFREHYSSLCSLSDQLAGKILVDVSNPTEQEHLQHRESNAEYLASLFPTCTVVKAFNVISAWTLQAGPRDGNRQVPICGDQPEAKRAVSEMALAMGFMPVDMGSLASAWEVEAMPLRLLPAWKVPTLLALGLFVCFYAYNFVRDVLQPYVQESQNKFFKLPVSVVNTTLPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFCAALHALYSFCLPLRRAHRYDLVNLAVKQVLANKSHLWVEEEVWRMEIYLSLGVLALGTLSLLAVTSLPSIANSLNWREFSFVQSSLGFVALVLSTLHTLTYGWTRAFEESRYKFYLPPTFTLTLLVPCVVILAKALFLLPCISRRLARIRRGWERESTIKFTLPTDHALAEKTSHV
|
| biopax3:standardName |
Metalloreductase STEAP3
|