| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. SUBUNIT: Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL (By similarity). TISSUE SPECIFICITY: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Barely detectable in liver and spleen. SIMILARITY: Belongs to the PI3K p85 subunit family. SIMILARITY: Contains 2 SH2 domains. GENE SYNONYMS:Pik3r3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 461 AA; 54254 MW; 6467D88447CC562B CRC64;
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| biopax3:xref | |
| biopax3:displayName |
P55G_RAT
|
| biopax3:name |
PI3-kinase regulatory subunit gamma,
PI3-kinase subunit p55-gamma,
PI3K regulatory subunit gamma,
Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma,
Pik3r3,
PtdIns-3-kinase regulatory subunit gamma,
PtdIns-3-kinase regulatory subunit p55-gamma,
p55PIK
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPVTSAVTNGMKDCFVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGNYGFSEPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKDYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKVRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHRGVRQRRLNAWLGIKSEDTDESYFINEDDESLPHYDEKTWFVEDVNRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKPCVIYSPARGYGFAEPYNLYGSLKELVLHYQQTSLVQHNDSLNVTLAYPVHAQMPSLCR
|
| biopax3:standardName |
Phosphatidylinositol 3-kinase regulatory subunit gamma
|