| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity). SUBUNIT: Interacts with RELA; the interaction requires the nuclear import signal. Interacts with NKIRAS1 and NKIRAS2. Part of a 70-90 kDa complex at least consisting of CHUK, IKBKB, NFKBIA, RELA, IKBKAP and MAP3K14. Interacts with HBV protein X. Interacts with RWDD3; the interaction enhances sumoylation. Interacts (when phosphorylated at the 2 serine residues in the destruction motif D-S-G-X(2,3,4)-S) with BTRC. Associates with the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC; the association is mediated via interaction with BTRC. Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with RELA; RELA interacts directly with NFKBIA (By similarity). Interacts with PRMT2. Interacts with PRKACA in platelets; this interaction is disrupted by thrombin and collagen (By similarity). Interacts with HIF1AN (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export (By similarity). INDUCTION: During liver regeneration. PTM: Phosphorylated; disables inhibition of NF-kappa-B DNA-binding activity. Phosphorylation at positions 32 and 36 is prerequisite to recognition by UBE2D3 leading to polyubiquitination and subsequent degradation (By similarity). PTM: Sumoylated; sumoylation requires the presence of the nuclear import signal (By similarity). PTM: Monoubiquitinated at Lys-21 and/or Lys-22 by UBE2D3. Ubiquitin chain elongation is then performed by CDC34 in cooperation with the SCF(FBXW11) E3 ligase complex, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. The resulting polyubiquitination leads to protein degradation. Also ubiquitinated by SCF(BTRC) following stimulus-dependent phosphorylation at Ser-32 and Ser-36 (By similarity). SIMILARITY: Belongs to the NF-kappa-B inhibitor family. SIMILARITY: Contains 4 ANK repeats. GENE SYNONYMS:Nfkbia Ikba. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 314 AA; 35017 MW; CC4C9D0F6CDDA950 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
IKBA_RAT
|
| biopax3:name |
I-kappa-B-alpha,
IkB-alpha,
IkappaBalpha,
Nfkbia,
RL/IF-1
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:IKBA_RAT_1,
urn:biopax:ModificationFeature:IKBA_RAT_2,
urn:biopax:ModificationFeature:IKBA_RAT_3,
urn:biopax:ModificationFeature:IKBA_RAT_4,
urn:biopax:ModificationFeature:IKBA_RAT_5,
urn:biopax:ModificationFeature:IKBA_RAT_6,
urn:biopax:ModificationFeature:IKBA_RAT_7,
urn:biopax:ModificationFeature:IKBA_RAT_8,
urn:biopax:ModificationFeature:IKBA_RAT_9
|
| biopax3:organism | |
| biopax3:sequence |
MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEDYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKTLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLGIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQTLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL
|
| biopax3:standardName |
NF-kappa-B inhibitor alpha
|