| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by autophosphorylation on Thr-1381 and Thr-1393 following oligomerization. SUBUNIT: Binds both upstream activators and downstream substrates in multimolecular complexes through its N-terminus. Oligomerizes after binding MAP4K2 or TRAF2. Interacts (via the kinase catalytic domain) with STK38 (By similarity). SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Most highly expressed in spleen, kidney and lung. PTM: Autophosphorylated. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 RING-type zinc finger. SIMILARITY: Contains 1 SWIM-type zinc finger. GENE SYNONYMS:Map3k1 Mekk Mekk1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1493 AA; 161315 MW; 8C5F29F866898524 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
M3K1_RAT
|
| biopax3:name |
2.7.11.25,
MAPK/ERK kinase kinase 1,
MEK kinase 1,
MEKK 1,
Map3k1
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:M3K1_RAT_1,
urn:biopax:ModificationFeature:M3K1_RAT_10,
urn:biopax:ModificationFeature:M3K1_RAT_11,
urn:biopax:ModificationFeature:M3K1_RAT_12,
urn:biopax:ModificationFeature:M3K1_RAT_13,
urn:biopax:ModificationFeature:M3K1_RAT_14,
urn:biopax:ModificationFeature:M3K1_RAT_15,
urn:biopax:ModificationFeature:M3K1_RAT_16,
urn:biopax:ModificationFeature:M3K1_RAT_17,
urn:biopax:ModificationFeature:M3K1_RAT_18,
urn:biopax:ModificationFeature:M3K1_RAT_19,
urn:biopax:ModificationFeature:M3K1_RAT_2,
urn:biopax:ModificationFeature:M3K1_RAT_3,
urn:biopax:ModificationFeature:M3K1_RAT_4,
urn:biopax:ModificationFeature:M3K1_RAT_5,
urn:biopax:ModificationFeature:M3K1_RAT_6,
urn:biopax:ModificationFeature:M3K1_RAT_7,
urn:biopax:ModificationFeature:M3K1_RAT_8,
urn:biopax:ModificationFeature:M3K1_RAT_9
|
| biopax3:organism | |
| biopax3:sequence |
MAAAAGDRASSSGFPGAAAASPEAGGGGGALQGSGAPAAGAGLLRETGSAGRERADWRRQQLRKVRSVELDQLPEQPLFLTASPPCPSTSPSPEPADAAAGASGFQPAAGPPPPGAASRCGSHSAELAAARDSGARSPAGAEPPSAAAPSGREMENKETLKGLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEMSNLAAELQGEGQAGSAAPAPKGRRSPSPGSSPSGRSGKPESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYSPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCGRGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNCHTLSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVDSPTSLRGVQQPSSPQQPVAGSQRRNQESNFNLTHYGTQQIPPAYKDLAEPWIQAFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANGESTGTSGGGSGGSLSAGAASGSSQPSISGDVVEAFCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGNQAESNNWQELLGRLCLIDRLLLEISAEFYPHIVSTDVSQAEPVEIRYKKLLSLLAFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPPLFSKLVTMLSASGSSHFARMRRRLMAIADEVEIAEVIQLGSEDTLDGQQDSSQALAPPRYPESSSLEHTAHVEKTGKGLKATRLSASSEDISDRLAGVSVGLPSSATTEQPKPTVQTKGRPHSQCLNSSPLSPPQLMFPAISAPCSSAPSVPAGSVTDASKHRPRAFVPCKIPSASPQTQRKFSLQFQRTCSENRDSEKLSPVFTQSRPPPSSNIHRAKASRPVPGSTSKLGDASKNSMTLDLNSASQCDDSFGSGSNSGSAVIPSEETAFTPAEDKCRLDVNPELNSSIEDLLEASMPSSDTTVTFKSEVAVLSPEKAESDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQDALPIVPQLQVENGEDIIIIQQDTPETLPGHTKANEPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYNLFIEWMAGASVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSRELLKHPVFRTTW
|
| biopax3:standardName |
Mitogen-activated protein kinase kinase kinase 1
|