| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritionnal and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids. SUBUNIT: Homodimer; disulfide-linked (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q5T6X5-1; Sequence=Displayed; Note=Major isoform; Name=2; IsoId=Q5T6X5-2; Sequence=VSP_016454; Name=3; IsoId=Q5T6X5-3; Sequence=VSP_016455; TISSUE SPECIFICITY: Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues. PTM: N-glycosylated (By similarity). SIMILARITY: Belongs to the G-protein coupled receptor 3 family. SEQUENCE CAUTION: Sequence=BAC05904.1; Type=Erroneous gene model prediction; GENE SYNONYMS:GPRC6A. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 926 AA; 104753 MW; 2019C884FF092EEF CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:18510,
urn:biopax:RelationshipXref:NCBI GENE_222545,
urn:biopax:RelationshipXref:REFSEQ_NP_683766,
urn:biopax:UnificationXref:UNIPROT_Q5T6X5,
urn:biopax:UnificationXref:UNIPROT_Q6JK43,
urn:biopax:UnificationXref:UNIPROT_Q6JK44,
urn:biopax:UnificationXref:UNIPROT_Q8NGU8,
urn:biopax:UnificationXref:UNIPROT_Q8NHZ9,
urn:biopax:UnificationXref:UNIPROT_Q8TDT6
|
| biopax3:displayName |
GPC6A_HUMAN
|
| biopax3:name |
G-protein coupled receptor GPCR33,
GPRC6A,
hGPCR33,
hGPRC6A
|
| biopax3:organism | |
| biopax3:sequence |
MAFLIILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFEISVFLQTLAMIHSIEMINNSTLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFKCDYSSYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINKMWIASDNWSTATKITTIPNVKKIGKVVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDLCQARDCQNPNAFQPWELLGVLKNVTFTDGWNSFHFDAHGDLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGKYENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYGILYCTFIPKCYVIICKQEINTKSAFLKMIYSYSSHSVSSIALSPASLDSMSGNVTMTNPSSSGKSATWQKSKDLQAQAFAHICRENATSVSKTLPRKRMSSI
|
| biopax3:standardName |
G-protein coupled receptor family C group 6 member A
|