| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May play a role in the transcriptional regulation of spermatogenesis. Seems to have a structural ATP-independent role in the reorganization of acetylated chromatin. SUBUNIT: Interacts with histone H4 acetylated N-terminus (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q58F21-1; Sequence=Displayed; Name=2; Synonyms=BRDT-NY; IsoId=Q58F21-2; Sequence=VSP_019118; TISSUE SPECIFICITY: Testis-specific. A 3-fold higher expression is seen in adult testis than in embryo testis. Expression seems to be correlated with histone H4 hyperacetylation during the haploid phase of spermatogenesis (spermiogenesis). No expression, or very low expression is seen in patients' testes with abnormal spermatogenesis. Expressed in cancers such as non-small cell lung cancer and squamous cell carcinomas of the head and neck as well as of esophagus, but not in melanoma or in cancers of the colon, breast, kidney and bladder. DEVELOPMENTAL STAGE: Expressed in embryo testis. DOMAIN: The two bromodomains are involved in the specific recognition of histone H4 acetylated N-terminus (By similarity). SIMILARITY: Contains 2 bromo domains. SEQUENCE CAUTION: Sequence=AAH47900.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH62700.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; GENE SYNONYMS:BRDT. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 947 AA; 107954 MW; 09C0FD8690E217BB CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:1105,
urn:biopax:RelationshipXref:NCBI GENE_676,
urn:biopax:RelationshipXref:REFSEQ_NP_001229734,
urn:biopax:RelationshipXref:REFSEQ_NP_001229735,
urn:biopax:RelationshipXref:REFSEQ_NP_001229736,
urn:biopax:RelationshipXref:REFSEQ_NP_001229737,
urn:biopax:RelationshipXref:REFSEQ_NP_001229739,
urn:biopax:RelationshipXref:REFSEQ_NP_001717,
urn:biopax:RelationshipXref:REFSEQ_NP_997072,
urn:biopax:UnificationXref:UNIPROT_O14789,
urn:biopax:UnificationXref:UNIPROT_Q58F21,
urn:biopax:UnificationXref:UNIPROT_Q6P5T1,
urn:biopax:UnificationXref:UNIPROT_Q7Z4A6,
urn:biopax:UnificationXref:UNIPROT_Q8IWI6
|
| biopax3:displayName |
BRDT_HUMAN
|
| biopax3:name |
BRDT,
CT9,
Cancer/testis antigen 9,
RING3-like protein
|
| biopax3:organism | |
| biopax3:sequence |
MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGDSDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
|
| biopax3:standardName |
Bromodomain testis-specific protein
|