| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. SUBUNIT: Interacts with FLNA (via N-terminus) (By similarity). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1C. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with TBP and RRN3. SUBCELLULAR LOCATION: Nucleus, nucleolus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q53T94-1; Sequence=Displayed; Name=2; IsoId=Q53T94-2; Sequence=VSP_021677; Note=No experimental confirmation available; Name=3; IsoId=Q53T94-3; Sequence=VSP_042954; Note=No experimental confirmation available; DOMAIN: Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (PubMed:21921198 and PubMed:21921199). SIMILARITY: Belongs to the RRN7/TAF1B family. SIMILARITY: Contains 1 RRN7-type zinc finger. SEQUENCE CAUTION: Sequence=AAA62863.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS:TAF1B. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 588 AA; 68832 MW; CE45DE622E28FD6E CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11533,
urn:biopax:RelationshipXref:NCBI GENE_9014,
urn:biopax:RelationshipXref:REFSEQ_NP_005671,
urn:biopax:UnificationXref:UNIPROT_B4DI42,
urn:biopax:UnificationXref:UNIPROT_F8WD72,
urn:biopax:UnificationXref:UNIPROT_Q15574,
urn:biopax:UnificationXref:UNIPROT_Q53T94,
urn:biopax:UnificationXref:UNIPROT_Q8WVC3
|
| biopax3:displayName |
TAF1B_HUMAN
|
| biopax3:name |
RNA polymerase I-specific TBP-associated factor 63 kDa,
TAF1B,
TAFI63,
TATA box-binding protein-associated factor 1B,
TBP-associated factor 1B,
Transcription initiation factor SL1/TIF-IB subunit B
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| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MDLEEAEEFKERCTQCAAVSWGLTDEGKYYCTSCHNVTERYQEVTNTDLIPNTQIKALNRGLKKKNNTEKGWDWYVCEGFQYILYQQAEALKNLGVGPELKNDVLHNFWKRYLQKSKQAYCKNPVYTTGRKPTVLEDNLSHSDWASEPELLSDVSCPPFLESGAESQSDIHTRKPFPVSKASQSETSVCSGSLDGVEYSQRKEKGIVKMTMPQTLAFCYLSLLWQREAITLSDLLRFVEEDHIPYINAFQHFPEQMKLYGRDRGIFGIESWPDYEDIYKKTVEVGTFLDLPRFPDITEDCYLHPNILCMKYLMEVNLPDEMHSLTCHVVKMTGMGEVDFLTFDPIAKMAKTVKYDVQAVAIIVVVLKLLFLLDDSFEWSLSNLAEKHNEKNKKDKPWFDFRKWYQIMKKAFDEKKQKWEEARAKYLWKSEKPLYYSFVDKPVAYKKREMVVNLQKQFSTLVESTATAGKKSPSSFQFNWTEEDTDRTCFHGHSLQGVLKEKGQSLLTKNSLYWLSTQKFCRCYCTHVTTYEESNYSLSYQFILNLFSFLLRIKTSLLHEEVSLVEKKLFEKKYSVKRKKSRSKKVRRH
|
| biopax3:standardName |
TATA box-binding protein-associated factor RNA polymerase I subunit B
|