| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. The activity is greater against mismatches (U/G) than against matches (U/A). Excised uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5- hydroxymethyluracil (hmU)] in ssDNA and dsDNA but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine) and other oxidized damage. The activity is damage specificity and salt concentration-dependent. The general order of the preference for ssDNA and dsDNA is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at the low salt concentration. At the high concentration dsDNA (G pair) > dsDNA (A pair) > ssDNA. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q53HV7-1; Sequence=Displayed; Name=2; IsoId=Q53HV7-2; Sequence=VSP_015150, VSP_015151; Note=No experimental confirmation available; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/smug1/"; GENE SYNONYMS:SMUG1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 270 AA; 29862 MW; 2AB18F6F757F6DD7 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:17148,
urn:biopax:RelationshipXref:NCBI GENE_23583,
urn:biopax:RelationshipXref:REFSEQ_NP_001230716,
urn:biopax:RelationshipXref:REFSEQ_NP_001230717,
urn:biopax:RelationshipXref:REFSEQ_NP_001230718,
urn:biopax:RelationshipXref:REFSEQ_NP_001230719,
urn:biopax:RelationshipXref:REFSEQ_NP_001230720,
urn:biopax:RelationshipXref:REFSEQ_NP_055126,
urn:biopax:UnificationXref:UNIPROT_A8K2K9,
urn:biopax:UnificationXref:UNIPROT_O95862,
urn:biopax:UnificationXref:UNIPROT_Q0D2M0,
urn:biopax:UnificationXref:UNIPROT_Q53HV7,
urn:biopax:UnificationXref:UNIPROT_Q8NB71,
urn:biopax:UnificationXref:UNIPROT_Q9BWC8
|
| biopax3:displayName |
SMUG1_HUMAN
|
| biopax3:name |
3.2.2.-,
SMUG1
|
| biopax3:organism | |
| biopax3:sequence |
MPQAFLLGSIHEPAGALMEPQPCPGSLAESFLEEELRLNAELSQLQFSEPVGIIYNPVEYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVSMVRDWLGIVGPVLTPPQEHPKRPVLGLECPQSEVSGARFWGFFRNLCGQPEVFFHHCFVHNLCPLLFLAPSGRNLTPAELPAKQREQLLGICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLMPEVQVEGLLHPSPRNPQANKGWEAVAKERLNELGLLPLLLK
|
| biopax3:standardName |
Single-strand selective monofunctional uracil DNA glycosylase
|