| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth. CATALYTIC ACTIVITY: ATP + acylglycerol = ADP + acyl-sn-glycerol 3- phosphate. CATALYTIC ACTIVITY: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl- sn-glycerol 3-phosphate. COFACTOR: Magnesium. PATHWAY: Lipid metabolism; glycerolipid metabolism. SUBCELLULAR LOCATION: Mitochondrion membrane. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q53H12-1; Sequence=Displayed; Name=2; IsoId=Q53H12-2; Sequence=VSP_020925, VSP_020926; Note=No experimental confirmation available; TISSUE SPECIFICITY: Highly expressed in muscle, heart, kidney and brain. DISEASE: Defects in AGK are the cause of mitochondrial DNA depletion syndrome type 10 (MTDPS10) [MIM:212350]. An autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Mental development is normal, but affected individuals may die early from cardiomyopathy. MISCELLANEOUS: Overexpressed in prostate cancer, suggesting that it may play a role in initiation and progression of prostate cancer, processes in which LPA plays key roles. SIMILARITY: Contains 1 DAGKc domain. GENE SYNONYMS:AGK MULK. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 422 AA; 47137 MW; F9D85658616B8970 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:21869,
urn:biopax:RelationshipXref:NCBI GENE_55750,
urn:biopax:RelationshipXref:REFSEQ_NP_060708,
urn:biopax:UnificationXref:UNIPROT_Q53H12,
urn:biopax:UnificationXref:UNIPROT_Q75KN1,
urn:biopax:UnificationXref:UNIPROT_Q96GC3,
urn:biopax:UnificationXref:UNIPROT_Q9NP48
|
| biopax3:displayName |
AGK_HUMAN
|
| biopax3:name |
2.7.1.107,
2.7.1.94,
AGK,
HsMuLK,
MuLK,
Multi-substrate lipid kinase,
Multiple substrate lipid kinase,
hAGK
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATLAIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHVEGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSPTQ
|
| biopax3:standardName |
Acylglycerol kinase, mitochondrial
|