| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=215 uM for 1,2-naphthoquinone; SUBUNIT: Homodimer. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Comment=UV radiation favors the production of isoform 2; Name=1; IsoId=Q53FA7-1; Sequence=Displayed; Note=Major isoform under normal light conditions; Name=2; Synonyms=PIG3AS; IsoId=Q53FA7-2; Sequence=VSP_015783, VSP_015784; Note=Major isoform under UV light exposure. Undergoes rapid proteolytic degradation by the proteasome; INDUCTION: Isoform 1 and isoform 2 are both activated by p53/TP53, doxorubicin, etoposide and ionizing radiation. Isoform 2 is highly activated by UV radiation. SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. SEQUENCE CAUTION: Sequence=AAC39535.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tp53i3/"; GENE SYNONYMS:TP53I3 PIG3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 332 AA; 35536 MW; C5A33C46B3F96473 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:19373,
urn:biopax:RelationshipXref:NCBI GENE_9540,
urn:biopax:RelationshipXref:REFSEQ_NP_001193731,
urn:biopax:RelationshipXref:REFSEQ_NP_004872,
urn:biopax:RelationshipXref:REFSEQ_NP_671713,
urn:biopax:UnificationXref:UNIPROT_D6W533,
urn:biopax:UnificationXref:UNIPROT_O14679,
urn:biopax:UnificationXref:UNIPROT_O14685,
urn:biopax:UnificationXref:UNIPROT_Q38G78,
urn:biopax:UnificationXref:UNIPROT_Q53FA7,
urn:biopax:UnificationXref:UNIPROT_Q6JLE7,
urn:biopax:UnificationXref:UNIPROT_Q9BWB8
|
| biopax3:displayName |
QORX_HUMAN
|
| biopax3:name |
1.-.-.-,
TP53I3,
Tumor protein p53-inducible protein 3,
p53-induced gene 3 protein
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MLAVHFDKPGGPENLYVKEVAKPSPGEGEVLLKVAASALNRADLMQRQGQYDPPPGASNILGLEASGHVAELGPGCQGHWKIGDTAMALLPGGGQAQYVTVPEGLLMPIPEGLTLTQAAAIPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAAIQLTRMAGAIPLVTAGSQKKLQMAEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDCIGGSYWEKNVNCLALDGRWVLYGLMGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQMLVNAFTEQILPHFSTEGPQRLLPVLDRIYPVTEIQEAHKYMEANKNIGKIVLELPQ
|
| biopax3:standardName |
Quinone oxidoreductase PIG3
|