| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. SUBUNIT: Interacts with FLII. Interacts with MYD88. Competes with FLII for MyD88-binding, even in the absence of LPS. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q32MZ4-1; Sequence=Displayed; Name=2; IsoId=Q32MZ4-2; Sequence=VSP_020265; Name=3; IsoId=Q32MZ4-3; Sequence=VSP_020264, VSP_020265; TISSUE SPECIFICITY: Ubiquitously expressed. DEVELOPMENTAL STAGE: Widely expressed in fetal tissues. SIMILARITY: Belongs to the LRRFIP family. SEQUENCE CAUTION: Sequence=AAH01385.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAY14672.1; Type=Erroneous gene model prediction; GENE SYNONYMS:LRRFIP1 GCF2 TRIP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 808 AA; 89253 MW; 4E6140DF2471A7C9 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:6702,
urn:biopax:RelationshipXref:NCBI GENE_9208,
urn:biopax:RelationshipXref:REFSEQ_NP_001131024,
urn:biopax:RelationshipXref:REFSEQ_NP_001131025,
urn:biopax:RelationshipXref:REFSEQ_NP_004726,
urn:biopax:UnificationXref:UNIPROT_O75766,
urn:biopax:UnificationXref:UNIPROT_O75799,
urn:biopax:UnificationXref:UNIPROT_Q32MZ4,
urn:biopax:UnificationXref:UNIPROT_Q32MZ5,
urn:biopax:UnificationXref:UNIPROT_Q53T49,
urn:biopax:UnificationXref:UNIPROT_Q6PKG2
|
| biopax3:displayName |
LRRF1_HUMAN
|
| biopax3:name |
GC-binding factor 2,
LRR FLII-interacting protein 1,
LRRFIP1,
TAR RNA-interacting protein
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:LRRF1_HUMAN_1,
urn:biopax:ModificationFeature:LRRF1_HUMAN_10,
urn:biopax:ModificationFeature:LRRF1_HUMAN_11,
urn:biopax:ModificationFeature:LRRF1_HUMAN_12,
urn:biopax:ModificationFeature:LRRF1_HUMAN_13,
urn:biopax:ModificationFeature:LRRF1_HUMAN_14,
urn:biopax:ModificationFeature:LRRF1_HUMAN_15,
urn:biopax:ModificationFeature:LRRF1_HUMAN_16,
urn:biopax:ModificationFeature:LRRF1_HUMAN_2,
urn:biopax:ModificationFeature:LRRF1_HUMAN_3,
urn:biopax:ModificationFeature:LRRF1_HUMAN_4,
urn:biopax:ModificationFeature:LRRF1_HUMAN_5,
urn:biopax:ModificationFeature:LRRF1_HUMAN_6,
urn:biopax:ModificationFeature:LRRF1_HUMAN_7,
urn:biopax:ModificationFeature:LRRF1_HUMAN_8,
urn:biopax:ModificationFeature:LRRF1_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MTSPAAAQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSASDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTEASIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDTLKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILNSEIATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRASEVEVKNEIVANVGKREILHNTEKEQHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLGTLAGATYEEQVQSQILESSSLPENTVQVESNEVMGAPDDRTRTPLEPSNCWSDLDGGNHTENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDDKCMVEVPQELETSTGHSLEKEFTNQEAAEPKEVPAHSTEVGRDHNEEEGEETGLRDEKPIKTEVPGSPAGTEGNCQEATGPSTVDTQNEPLDMKEPDEEKSDQQGEALDSSQKKTKNKKKKNKKKKSPVPVETLKDVKKELTYQNTDLSEIKEEEQVKSTDRKSAVEAQNEVTENPKQKIAAESSENVDCPENPKIKLDGKLDQEGDDVQTAAEEVLADGDTLDFEDDTVQSSGPRAGGEELDEGVAKDNAKIDGATQSSPAEPKSEDADRCTLPEHESPSQDISDACEAESTERCEMSEHPSQTVRKALDSNSLENDDLSAPGREPGHFNPESREDTRGGNEKGKSKEDCTMS
|
| biopax3:standardName |
Leucine-rich repeat flightless-interacting protein 1
|