| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values. CATALYTIC ACTIVITY: CMP-N-acetylneuraminate + beta-D-galactosyl- 1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D- galactosaminyl-R. PATHWAY: Protein modification; protein glycosylation. SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity). Secreted (By similarity). Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). TISSUE SPECIFICITY: Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas. Scarcely detectable in lung and kidney. PTM: The soluble form derives from the membrane form by proteolytic processing (By similarity). SIMILARITY: Belongs to the glycosyltransferase 29 family. WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL2"; WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=ST3Gal II; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_623"; GENE SYNONYMS:ST3GAL2 SIAT4B. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 350 AA; 40173 MW; E7E40CF26D9CB725 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
SIA4B_HUMAN
|
| biopax3:name |
2.4.99.4,
Alpha 2,3-ST 2,
Beta-galactoside alpha-2,3-sialyltransferase 2,
Gal-NAc6S,
Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase,
SIAT4-B,
ST3GAL2,
ST3Gal II,
ST3GalA.2,
ST3GalII,
Sialyltransferase 4B
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| biopax3:organism | |
| biopax3:sequence |
MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALDGTHRVKLVPGYAGLQRLSKERLSGKSCACRRCMGDAGASDWFDSHFDGNISPVWTRENMDLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMNQAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIASALSTGQIRFTYAPVKSFLRVDKEKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEVNVYGFGADSRGNWHHYWENNRYAGEFRKTGVHDADFEAHIIDMLAKASKIEVYRGN
|
| biopax3:standardName |
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
|