| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. SUBUNIT: Associates with beta-catenin. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, filopodium. Cell projection, invadopodium. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: Composed of four beta-trefoil domains. PTM: Phosphorylation on Ser-39 inhibits the actin-binding ability of fascin. SIMILARITY: Belongs to the fascin family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FSCN1ID44342ch7p22.html"; GENE SYNONYMS:FSCN1 FAN1 HSN SNL. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 493 AA; 54530 MW; C1453714BED6109A CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11148,
urn:biopax:RelationshipXref:NCBI GENE_6624,
urn:biopax:RelationshipXref:REFSEQ_NP_003079,
urn:biopax:UnificationXref:UNIPROT_A6NI89,
urn:biopax:UnificationXref:UNIPROT_B2RE97,
urn:biopax:UnificationXref:UNIPROT_Q16658,
urn:biopax:UnificationXref:UNIPROT_Q96IC5,
urn:biopax:UnificationXref:UNIPROT_Q9BRF1
|
| biopax3:displayName |
FSCN1_HUMAN
|
| biopax3:name |
55 kDa actin-bundling protein,
FSCN1,
Singed-like protein,
p55
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MTANGTAEAVQIQFGLINCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPGPDCRFLIVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQTVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTADHRFLRHDGRLVARPEPATGYTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTKKCAFRTHTGKYWTLTATGGVQSTASSKNASCYFDIEWRDRRITLRASNGKFVTSKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSAVTSSGDTPVDFFFEFCDYNKVAIKVGGRYLKGDHAGVLKASAETVDPASLWEY
|
| biopax3:standardName |
Fascin
|