| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. SUBUNIT: Forms a complex with Hsp90/HSP90AB1 and CDK6. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1. SUBCELLULAR LOCATION: Cytoplasm. PTM: Constitutively sumoylated by UBE2I. SIMILARITY: Belongs to the CDC37 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc37/"; GENE SYNONYMS:CDC37 CDC37A. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 378 AA; 44468 MW; 55BFEFFF3C2A5442 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
CDC37_HUMAN
|
| biopax3:name |
CDC37,
Hsp90 chaperone protein kinase-targeting subunit,
p50Cdc37
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:CDC37_HUMAN_1,
urn:biopax:ModificationFeature:CDC37_HUMAN_2,
urn:biopax:ModificationFeature:CDC37_HUMAN_3,
urn:biopax:ModificationFeature:CDC37_HUMAN_4,
urn:biopax:ModificationFeature:CDC37_HUMAN_5,
urn:biopax:ModificationFeature:CDC37_HUMAN_6,
urn:biopax:ModificationFeature:CDC37_HUMAN_7,
urn:biopax:ModificationFeature:CDC37_HUMAN_8,
urn:biopax:ModificationFeature:CDC37_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MVDYSVWDHIEVSDDEDETHPNIDTASLFRWRHQARVERMEQFQKEKEELDRGCRECKRKVAECQRKLKELEVAEGGKAELERLQAEAQQLRKEERSWEQKLEEMRKKEKSMPWNVDTLSKDGFSKSMVNTKPEKTEEDSEEVREQKHKTFVEKYEKQIKHFGMLRRWDDSQKYLSDNVHLVCEETANYLVIWCIDLEVEEKCALMEQVAHQTIVMQFILELAKSLKVDPRACFRQFFTKIKTADRQYMEGFNDELEAFKERVRGRAKLRIEKAMKEYEEEERKKRLGPGGLDPVEVYESLPEELQKCFDVKDVQMLQDAISKMDPTDAKYHMQRCIDSGLWVPNSKASEAKEGEEAGPGDPLLEAVPKTGDEKDVSV
|
| biopax3:standardName |
Hsp90 co-chaperone Cdc37
|