| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. SUBUNIT: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=TAB1alpha; IsoId=Q15750-1; Sequence=Displayed; Name=2; Synonyms=TAB1beta; IsoId=Q15750-2; Sequence=VSP_042024; Note=Does not bind nor activate MAP3K7/TAK1; TISSUE SPECIFICITY: Ubiquitous. PTM: Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP. SIMILARITY: Contains 1 PP2C-like domain. GENE SYNONYMS:TAB1 MAP3K7IP1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 504 AA; 54644 MW; A45743288718983A CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:18157,
urn:biopax:RelationshipXref:NCBI GENE_10454,
urn:biopax:RelationshipXref:REFSEQ_NP_006107,
urn:biopax:RelationshipXref:REFSEQ_NP_705717,
urn:biopax:UnificationXref:UNIPROT_Q15750,
urn:biopax:UnificationXref:UNIPROT_Q2PP09,
urn:biopax:UnificationXref:UNIPROT_Q8IZW2
|
| biopax3:displayName |
TAB1_HUMAN
|
| biopax3:name |
Mitogen-activated protein kinase kinase kinase 7-interacting protein 1,
TAB1,
TAK1-binding protein 1,
TGF-beta-activated kinase 1-binding protein 1
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPEDSWLKFRSENNCFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVERSFLESIDDALAEKASLQSQLPEGVPQHQLPPQYQKILERLKTLEREISGGAMAVVAVLLNNKLYVANVGTNRALLCKSTVDGLQVTQLNVDHTTENEDELFRLSQLGLDAGKIKQVGIICGQESTRRIGDYKVKYGYTDIDLLSAAKSKPIIAEPEIHGAQPLDGVTGFLVLMSEGLYKALEAAHGPGQANQEIAAMIDTEFAKQTSLDAVAQAVVDRVKRIHSDTFASGGERARFCPRHEDMTLLVRNFGYPLGEMSQPTPSPAPAAGGRVYPVSVPYSSAQSTSKTSVTLSLVMPSQGQMVNGAHSASTLDEATPTLTNQSPTLTLQSTNTHTQSSSSSSDGGLFRSRPAHSLPPGEDGRVEPYVDFAEFYRLWSVDHGEQSVVTAP
|
| biopax3:standardName |
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
|