| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation. SUBUNIT: Interacts with THRB (via ligand-binding domain). Interacts with RELA and REL. Interacts with COMMD1 and inhibitor kappa B-interacting Ras-like NKIRAS1 and NKIRAS2. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15653-1; Sequence=Displayed; Name=2; IsoId=Q15653-2; Sequence=VSP_012409, VSP_012410; TISSUE SPECIFICITY: Expressed in all tissues examined. PTM: Phosphorylated; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. SIMILARITY: Belongs to the NF-kappa-B inhibitor family. SIMILARITY: Contains 6 ANK repeats. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/nfkbib/"; GENE SYNONYMS:NFKBIB IKBB TRIP9. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 356 AA; 37771 MW; E84575971B6F81CC CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:7798,
urn:biopax:RelationshipXref:NCBI GENE_4793,
urn:biopax:RelationshipXref:REFSEQ_NP_001230045,
urn:biopax:RelationshipXref:REFSEQ_NP_002494,
urn:biopax:UnificationXref:UNIPROT_A8K3F4,
urn:biopax:UnificationXref:UNIPROT_Q15653,
urn:biopax:UnificationXref:UNIPROT_Q96BJ7
|
| biopax3:displayName |
IKBB_HUMAN
|
| biopax3:name |
I-kappa-B-beta,
IkB-B,
IkB-beta,
IkappaBbeta,
NF-kappa-BIB,
NFKBIB,
TR-interacting protein 9,
TRIP-9,
Thyroid receptor-interacting protein 9
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MAGVACLGKAADADEWCDSGLGSLGPDAAAPGGPGLGAELGPGLSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKPLPDDPRPV
|
| biopax3:standardName |
NF-kappa-B inhibitor beta
|