| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. SUBUNIT: Binds U2AF2. Interacts with U1 snRNA. Binds EWSR1, FUS and TAF15. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Comment=Additional isoforms seem to exist; Name=1; Synonyms=SF1-HL1; IsoId=Q15637-1; Sequence=Displayed; Name=2; Synonyms=SF1-Bo, Bone; IsoId=Q15637-2; Sequence=VSP_008839; Name=3; Synonyms=ZFM1-A, ZFM1-ABCDEF; IsoId=Q15637-3; Sequence=VSP_008838; Name=4; Synonyms=ZFM1-B, ZFM1-ABCDF; IsoId=Q15637-4; Sequence=VSP_008835, VSP_008836; Name=5; IsoId=Q15637-5; Sequence=VSP_008833, VSP_008835; Note=No experimental confirmation available; Name=6; Synonyms=ZFM1-D, B6; IsoId=Q15637-6; Sequence=VSP_008834, VSP_008837; Note=Phosphorylated on Ser-463; TISSUE SPECIFICITY: Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart. PTM: Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463. SIMILARITY: Belongs to the BBP/SF1 family. SIMILARITY: Contains 1 CCHC-type zinc finger. SIMILARITY: Contains 1 KH domain. SEQUENCE CAUTION: Sequence=AAH00773.1; Type=Erroneous initiation; GENE SYNONYMS:SF1 ZFM1 ZNF162. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 639 AA; 68330 MW; EEBC6A02B29DAE4D CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:12950,
urn:biopax:RelationshipXref:NCBI GENE_7536,
urn:biopax:RelationshipXref:REFSEQ_NP_001171501,
urn:biopax:RelationshipXref:REFSEQ_NP_001171502,
urn:biopax:RelationshipXref:REFSEQ_NP_004621,
urn:biopax:RelationshipXref:REFSEQ_NP_973724,
urn:biopax:RelationshipXref:REFSEQ_NP_973726,
urn:biopax:RelationshipXref:REFSEQ_NP_973727,
urn:biopax:UnificationXref:UNIPROT_Q14818,
urn:biopax:UnificationXref:UNIPROT_Q14819,
urn:biopax:UnificationXref:UNIPROT_Q15637,
urn:biopax:UnificationXref:UNIPROT_Q15913,
urn:biopax:UnificationXref:UNIPROT_Q8IY00,
urn:biopax:UnificationXref:UNIPROT_Q92744,
urn:biopax:UnificationXref:UNIPROT_Q92745,
urn:biopax:UnificationXref:UNIPROT_Q969H7,
urn:biopax:UnificationXref:UNIPROT_Q9BW01,
urn:biopax:UnificationXref:UNIPROT_Q9UEI0
|
| biopax3:displayName |
SF01_HUMAN
|
| biopax3:name |
BBP,
Mammalian branch point-binding protein,
SF1,
Transcription factor ZFM1,
Zinc finger gene in MEN1 locus,
Zinc finger protein 162,
mBBP
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPPPPQN
|
| biopax3:standardName |
Splicing factor 1
|