| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. SUBUNIT: Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. TISSUE SPECIFICITY: Found in all examined tissues. DOMAIN: Requires the intact DEATH domain to associate with TNFRSF1A/TNFR1. SIMILARITY: Contains 1 death domain. SEQUENCE CAUTION: Sequence=AAA98482.1; Type=Erroneous initiation; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/tradd/"; GENE SYNONYMS:TRADD. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 312 AA; 34247 MW; 5645D7E63E5FF05A CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
TRADD_HUMAN
|
| biopax3:name |
TNFR1-associated DEATH domain protein,
TNFRSF1A-associated via death domain,
TRADD
|
| biopax3:organism | |
| biopax3:sequence |
MAAGQNGHEEWVGSAYLFVESSLDKVVLSDAYAHPQQKVAVYRALQAALAESGGSPDVLQMLKIHRSDPQLIVQLRFCGRQPCGRFLRAYREGALRAALQRSLAAALAQHSVPLQLELRAGAERLDALLADEERCLSCILAQQPDRLRDEELAELEDALRNLKCGSGARGGDGEVASAPLQPPVPSLSEVKPPPPPPPAQTFLFQGQPVVNRPLSLKDQQTFARSVGLKWRKVGRSLQRGCRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAEDLLGLTDPNGGLA
|
| biopax3:standardName |
Tumor necrosis factor receptor type 1-associated DEATH domain protein
|