| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3. SUBUNIT: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q15572-1; Sequence=Displayed; Name=2; IsoId=Q15572-2; Sequence=VSP_015153, VSP_015154, VSP_015156; Note=No experimental confirmation available; Name=4; IsoId=Q15572-4; Sequence=VSP_038087; Note=No experimental confirmation available; Name=5; IsoId=Q15572-5; Sequence=VSP_038086; Note=No experimental confirmation available; Name=6; IsoId=Q15572-6; Sequence=VSP_015154; Note=No experimental confirmation available; PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE CAUTION: Sequence=BAD92831.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/taf1c/"; GENE SYNONYMS:TAF1C. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 869 AA; 95213 MW; 6AAFAF296D98A5DB CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11534,
urn:biopax:RelationshipXref:NCBI GENE_9013,
urn:biopax:RelationshipXref:REFSEQ_NP_001230085,
urn:biopax:RelationshipXref:REFSEQ_NP_001230086,
urn:biopax:RelationshipXref:REFSEQ_NP_001230087,
urn:biopax:RelationshipXref:REFSEQ_NP_001230088,
urn:biopax:RelationshipXref:REFSEQ_NP_005670,
urn:biopax:RelationshipXref:REFSEQ_NP_647610,
urn:biopax:UnificationXref:UNIPROT_B7Z5K5,
urn:biopax:UnificationXref:UNIPROT_B7Z5S4,
urn:biopax:UnificationXref:UNIPROT_B7Z908,
urn:biopax:UnificationXref:UNIPROT_B7Z9L7,
urn:biopax:UnificationXref:UNIPROT_Q15572,
urn:biopax:UnificationXref:UNIPROT_Q59F67,
urn:biopax:UnificationXref:UNIPROT_Q8N6V3
|
| biopax3:displayName |
TAF1C_HUMAN
|
| biopax3:name |
RNA polymerase I-specific TBP-associated factor 110 kDa,
TAF1C,
TAFI110,
TATA box-binding protein-associated factor 1C,
TBP-associated factor 1C,
Transcription initiation factor SL1/TIF-IB subunit C
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MDFPSSLRPALFLTGPLGLSDVPDLSFMCSWRDALTLPEAQPQNSENGALHVTKDLLWEPATPGPLPMLPPLIDPWDPGLTARDLLFRGGCRYRKRPRVVLDVTEQISRFLLDHGDVAFAPLGKLMLENFKLEGAGSRTKKKTVVSVKKLLQDLGGHQPWGCPWAYLSNRQRRFSILGGPILGTSVASHLAELLHEELVLRWEQLLLDEACTGGALAWVPGRTPQFGQLVYPAGGAQDRLHFQEVVLTPGDNPQFLGKPGRIQLQGPVRQVVTCTVQGESKALIYTFLPHWLTCYLTPGPFHPSSALLAVRSDYHCAVWKFGKQWQPTLLQAMQVEKGATGISLSPHLPGELAICSRSGAVCLWSPEDGLRQIYRDPETLVFRDSSSWRWADFTAHPRVLTVGDRTGVKMLDTQGPPGCGLLLFRLGAEASCQKGERVLLTQYLGHSSPKCLPPTLHLVCTQFSLYLVDERLPLVPMLKWNHGLPSPLLLARLLPPPRPSCVQPLLLGGQGGQLQLLHLAGEGASVPRLAGPPQSLPSRIDSLPAFPLLEPKIQWRLQERLKAPTIGLAAVVPPLPSAPTPGLVLFQLSAAGDVFYQQLRPQVDSSLRRDAGPPGDTQPDCHAPTASWTSQDTAGCSQWLKALLKVPLAPPVWTAPTFTHRQMLGSTELRREEEEGQRLGVLRKAMARGQLLLQRDLGSLPAAEPPPAPESGLEDKLSERLGEAWAGRGAAWWERQQGRTSEPGRQTRRPKRRTQLSSSFSLSGHVDPSEDTSSPHSPEWPPADALPLPPTTPPSQELTPDACAQGVPSEQRQMLRDYMAKLPPQRDTPGCATTPPHSQASSVRATRSQQHTPVLSSSQPLRKKPRMGF
|
| biopax3:standardName |
TATA box-binding protein-associated factor RNA polymerase I subunit C
|