Q15398

FUNCTION: Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. SUBUNIT: Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1- CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15398-2; Sequence=Displayed; Name=2; IsoId=Q15398-1; Sequence=VSP_015550; Note=No experimental confirmation available; TISSUE SPECIFICITY: Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. DEVELOPMENTAL STAGE: Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells. PTM: Ubiquitinated, leading to its degradation. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells. SIMILARITY: Belongs to the SAPAP family. CAUTION: It was localized to the spindle and the spindle pole (PubMed:12527899) but was later found to be localized to the spindle and to be excluded from the spindle pole (PubMed:15561729). SEQUENCE CAUTION: Sequence=BAA02797.3; Type=Erroneous initiation; Note=Translation N-terminally shortened; GENE SYNONYMS:DLGAP5 DLG7 KIAA0008. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 846 AA; 95115 MW; 588BAF238D6FFB72 CRC64;

DLGP5_HUMAN

urn:biopax:ModificationFeature:DLGP5_HUMAN_1, urn:biopax:ModificationFeature:DLGP5_HUMAN_10, urn:biopax:ModificationFeature:DLGP5_HUMAN_11, urn:biopax:ModificationFeature:DLGP5_HUMAN_12, urn:biopax:ModificationFeature:DLGP5_HUMAN_13, urn:biopax:ModificationFeature:DLGP5_HUMAN_14, urn:biopax:ModificationFeature:DLGP5_HUMAN_15, urn:biopax:ModificationFeature:DLGP5_HUMAN_16, urn:biopax:ModificationFeature:DLGP5_HUMAN_17, urn:biopax:ModificationFeature:DLGP5_HUMAN_18, urn:biopax:ModificationFeature:DLGP5_HUMAN_19, urn:biopax:ModificationFeature:DLGP5_HUMAN_2, urn:biopax:ModificationFeature:DLGP5_HUMAN_20, urn:biopax:ModificationFeature:DLGP5_HUMAN_21, urn:biopax:ModificationFeature:DLGP5_HUMAN_22, urn:biopax:ModificationFeature:DLGP5_HUMAN_23, urn:biopax:ModificationFeature:DLGP5_HUMAN_24, urn:biopax:ModificationFeature:DLGP5_HUMAN_25, urn:biopax:ModificationFeature:DLGP5_HUMAN_26, urn:biopax:ModificationFeature:DLGP5_HUMAN_27, urn:biopax:ModificationFeature:DLGP5_HUMAN_28, urn:biopax:ModificationFeature:DLGP5_HUMAN_29, urn:biopax:ModificationFeature:DLGP5_HUMAN_3, urn:biopax:ModificationFeature:DLGP5_HUMAN_4, urn:biopax:ModificationFeature:DLGP5_HUMAN_5, urn:biopax:ModificationFeature:DLGP5_HUMAN_6, urn:biopax:ModificationFeature:DLGP5_HUMAN_7, urn:biopax:ModificationFeature:DLGP5_HUMAN_8, urn:biopax:ModificationFeature:DLGP5_HUMAN_9

MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRHFGLKDVNIPTLEGRILVELDETSQGLVPEKTNVKPRAMKTILGDQRKQMLQKYKEEKQLQKLKEQREKAKRGIFKVGRYRPDMPCFLLSNQNAVKAEPKKAIPSSVRITRSKAKDQMEQTKIDNESDVRAIRPGPRQTSEKKVSDKEKKVVQPVMPTSLRMTRSATQAAKQVPRTVSSTTARKPVTRAANENEPEGKVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTNATSGMNPDGVLSKMENLPEINTAKIKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPSYTWTPLKTEVDESQATKEILAQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEEHVLNKNEATTKNLNGLPIKEVPSLERNEGRIAQPHHGVPYFRNILQSETEKLTSHCFEWDRKLELDIPDDAKDLIRTAVGQTRLLMKERFKQFEGLVDDCEYKRGIKETTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNNMNHNMNKNVFRKKVVSGIASKPKQDDAGRIAARNRLAAIKNAMRERIRQEECAETAVSVIPKEVDKIVFDAGFFRVESPVKLFSGLSVSSEGPSQRLGTPKSVNKAVSQSRNEMGIPQQTTSPENAGPQNTKSEHVKKTLFLSIPESRSSIEDAQCPGLPDLIEENHVVNKTDLKVDCLSSERMSLPLLAGGVADDINTNKKEGISDVVEGMELNSSITSQDVLMSSPEKNTASQNSILEEGETKISQSELFDNKSLTTECHLLDSPGLNCSNPFTQLERRHQEHARHISFGGNLITFSPLQPGEF