| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
CATALYTIC ACTIVITY: ATP + (R)-5-phosphomevalonate = ADP + (R)-5- diphosphomevalonate. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=25 uM for (R)-5-phosphomevalonate; KM=0.26 mM for ATP; Vmax=46.4 umol/min/mg enzyme with (R)-5-phosphomevalonate as substrate; Vmax=52 umol/min/mg enzyme with ATP as substrate; PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3. SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Peroxisome. TISSUE SPECIFICITY: Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung. INDUCTION: By sterol. GENE SYNONYMS:PMVK PMKI. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 192 AA; 21995 MW; D7E720D0DDCCA249 CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
PMVK_HUMAN
|
| biopax3:name |
2.7.4.2,
PMKase,
PMVK,
hPMK
|
| biopax3:organism | |
| biopax3:sequence |
MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL
|
| biopax3:standardName |
Phosphomevalonate kinase
|