| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism. CATALYTIC ACTIVITY: ATP + [pyruvate dehydrogenase (acetyl- transferring)] = ADP + [pyruvate dehydrogenase (acetyl- transferring)] phosphate. ENZYME REGULATION: Inhibited by AZD7545, dichloroacetate and radicicol. SUBUNIT: Interacts with the pyruvate dehydrogenase complex E2 subunit (DLAT). SUBCELLULAR LOCATION: Mitochondrion matrix. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q15120-1; Sequence=Displayed; Name=2; IsoId=Q15120-2; Sequence=VSP_043365; Note=No experimental confirmation available; TISSUE SPECIFICITY: Found almost exclusively in heart and skeletal muscle. SIMILARITY: Belongs to the PDK/BCKDK protein kinase family. SIMILARITY: Contains 1 histidine kinase domain. GENE SYNONYMS:PDK3 PDHK3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 406 AA; 46939 MW; EF2415D3F9D8D61E CRC64;
|
| biopax3:xref | |
| biopax3:displayName |
PDK3_HUMAN
|
| biopax3:name |
2.7.11.2,
PDK3,
Pyruvate dehydrogenase kinase isoform 3
|
| biopax3:organism | |
| biopax3:sequence |
MRLFRWLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQ
|
| biopax3:standardName |
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3, mitochondrial
|