| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons. SUBUNIT: Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other members such as NFATC4, NFATC3 or members of the activating protein-1 family, MAF, GATA4 and Cbp/p300 can also bind the complex. NFATC proteins bind to DNA as monomers. Interacts with CREBBP, GATA4, IRAK1, MAPK8, MAPK9 and RPS6KA3. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=24; Name=1; Synonyms=ID-IXL; IsoId=Q14934-1; Sequence=Displayed; Name=2; Synonyms=IA-IXL; IsoId=Q14934-2; Sequence=VSP_036701; Name=3; Synonyms=IA-IXi; IsoId=Q14934-3; Sequence=VSP_036701, VSP_036705; Note=Due to an intron retention; Name=4; Synonyms=IC-IXL; IsoId=Q14934-4; Sequence=VSP_036702; Name=5; Synonyms=IC-IXi; IsoId=Q14934-5; Sequence=VSP_036702, VSP_036705; Note=Due to an intron retention; Name=6; Synonyms=IB-IXL; IsoId=Q14934-6; Sequence=VSP_036703; Name=7; Synonyms=IB-IXi; IsoId=Q14934-7; Sequence=VSP_036703, VSP_036705; Note=Due to an intron retention; Name=8; Synonyms=ID-IXi; IsoId=Q14934-8; Sequence=VSP_036705; Note=Due to an intron retention; Name=9; Synonyms=IE-IXL; IsoId=Q14934-9; Sequence=VSP_036700; Name=10; Synonyms=IE-IXi; IsoId=Q14934-10; Sequence=VSP_036700, VSP_036705; Note=Due to an intron retention; Name=11; Synonyms=IA-IXS; IsoId=Q14934-11; Sequence=VSP_036701, VSP_036704; Name=12; Synonyms=IEi-IXL; IsoId=Q14934-12; Sequence=VSP_036699; Note=Due to an intron retention; Name=13; Synonyms=IEi-IXi; IsoId=Q14934-13; Sequence=VSP_036699, VSP_036705; Note=Due to an intron retention; Name=14; Synonyms=IC-IXS; IsoId=Q14934-14; Sequence=VSP_036702, VSP_036704; Name=15; Synonyms=IB-IXS; IsoId=Q14934-15; Sequence=VSP_036703, VSP_036704; Name=16; Synonyms=ID-IXS; IsoId=Q14934-16; Sequence=VSP_036704; Name=17; Synonyms=IE-IXS; IsoId=Q14934-17; Sequence=VSP_036700, VSP_036704; Name=18; Synonyms=IEi-IXS; IsoId=Q14934-18; Sequence=VSP_036699, VSP_036704; Note=Due to an intron retention; Name=19; Synonyms=IV-IXL; IsoId=Q14934-19; Sequence=VSP_036698; Name=20; Synonyms=IV-IXi; IsoId=Q14934-20; Sequence=VSP_036698, VSP_036705; Note=Due to an intron retention; Name=21; Synonyms=IV-IXS; IsoId=Q14934-21; Sequence=VSP_036698, VSP_036704; Name=22; Synonyms=VI-IXL; IsoId=Q14934-22; Sequence=VSP_036697; Name=23; Synonyms=VI-IXi; IsoId=Q14934-23; Sequence=VSP_036697, VSP_036705; Note=Due to an intron retention; Name=24; Synonyms=VI-IXS; IsoId=Q14934-24; Sequence=VSP_036697, VSP_036704; TISSUE SPECIFICITY: Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Detected in hippocampus. DOMAIN: Rel Similarity Domain (RSD) allows DNA-binding and cooperative interactions with AP1 factors (By similarity). PTM: Phosphorylated by NFATC-kinases; dephosphorylated by calcineurin. Phosphorylated on Ser-168 and Ser-170 by MTOR, IRAK1, MAPK7 and MAPK14, on Ser-213 and Ser-217 by MAPK8 and MAPK9, and on Ser-289 and Ser-344 by RPS6KA3. Phosphorylated by GSK3B. PTM: Ubiquitinated, leading to its degradation by the proteasome and reduced transcriptional activity. Ubiquitination and reduction in transcriptional activity can be further facilitated through GSK3B-dependent phosphorylation. Polyubiquitin linkage is mainly through 'Lys-48'. SIMILARITY: Contains 1 IPT/TIG domain. SIMILARITY: Contains 1 RHD (Rel-like) domain. GENE SYNONYMS:NFATC4 NFAT3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 902 AA; 95449 MW; AE94C5D1325D24D7 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:7778,
urn:biopax:RelationshipXref:NCBI GENE_4776,
urn:biopax:RelationshipXref:REFSEQ_NP_001129494,
urn:biopax:RelationshipXref:REFSEQ_NP_001185894,
urn:biopax:RelationshipXref:REFSEQ_NP_001185895,
urn:biopax:RelationshipXref:REFSEQ_NP_001185896,
urn:biopax:RelationshipXref:REFSEQ_NP_004545,
urn:biopax:UnificationXref:UNIPROT_B4DDG5,
urn:biopax:UnificationXref:UNIPROT_B4DY55,
urn:biopax:UnificationXref:UNIPROT_B5B2U7,
urn:biopax:UnificationXref:UNIPROT_B5B2U8,
urn:biopax:UnificationXref:UNIPROT_B5B2U9,
urn:biopax:UnificationXref:UNIPROT_B5B2V0,
urn:biopax:UnificationXref:UNIPROT_B5B2V1,
urn:biopax:UnificationXref:UNIPROT_B5B2V2,
urn:biopax:UnificationXref:UNIPROT_B5B2V3,
urn:biopax:UnificationXref:UNIPROT_B5B2V4,
urn:biopax:UnificationXref:UNIPROT_B5B2V5,
urn:biopax:UnificationXref:UNIPROT_B5B2V7,
urn:biopax:UnificationXref:UNIPROT_B5B2V8,
urn:biopax:UnificationXref:UNIPROT_B5B2V9,
urn:biopax:UnificationXref:UNIPROT_B5B2W0,
urn:biopax:UnificationXref:UNIPROT_B5B2W1,
urn:biopax:UnificationXref:UNIPROT_B5B2W2,
urn:biopax:UnificationXref:UNIPROT_B5B2W3,
urn:biopax:UnificationXref:UNIPROT_B5B2W4,
urn:biopax:UnificationXref:UNIPROT_B5B2W5,
urn:biopax:UnificationXref:UNIPROT_B5B2W6,
urn:biopax:UnificationXref:UNIPROT_B5B2W7,
urn:biopax:UnificationXref:UNIPROT_B5B2W8,
urn:biopax:UnificationXref:UNIPROT_B5B2W9,
urn:biopax:UnificationXref:UNIPROT_B5B2X0,
urn:biopax:UnificationXref:UNIPROT_Q14934,
urn:biopax:UnificationXref:UNIPROT_Q7Z598,
urn:biopax:UnificationXref:UNIPROT_Q96H68
|
| biopax3:displayName |
NFAC4_HUMAN
|
| biopax3:name |
NF-AT3,
NF-ATc4,
NFATC4,
NFATc4,
T-cell transcription factor NFAT3
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:NFAC4_HUMAN_1,
urn:biopax:ModificationFeature:NFAC4_HUMAN_2,
urn:biopax:ModificationFeature:NFAC4_HUMAN_3,
urn:biopax:ModificationFeature:NFAC4_HUMAN_4,
urn:biopax:ModificationFeature:NFAC4_HUMAN_5,
urn:biopax:ModificationFeature:NFAC4_HUMAN_6,
urn:biopax:ModificationFeature:NFAC4_HUMAN_7
|
| biopax3:organism | |
| biopax3:sequence |
MGAASCEDEELEFKLVFGEEKEAPPLGAGGLGEELDSEDAPPCCRLALGEPPPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGGAGGAGGGRVLECPSIRITSISPTPEPPAALEDNPDAWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLGSPLPSPRASPRPWTPEDPWSLYGPSPGGRGPEDSWLLLSAPGPTPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGSEPPPPPPLPLARDPGSPGPFDYVGAPPAESIPQKTRRTSSEQAVALPRSEEPASCNGKLPLGAEESVAPPGGSRKEVAGMDYLAVPSPLAWSKARIGGHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYSEKPLTLQMFIGTADERNLRPHAFYQVHRITGKMVATASYEAVVSGTKVLEMTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPIECSQRSAQELPQVEAYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEATVNRLQSNEVTLTLTVPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFRFLPVICKEEPLPDSSLRGFPSASATPFGTDMDFSPPRPPYPSYPHEDPACETPYLSEGFGYGMPPLYPQTGPPPSYRPGLRMFPETRGTTGCAQPPAVSFLPRPFPSDPYGGRGSSFSLGLPFSPPAPFRPPPLPASPPLEGPFPSQSDVHPLPAEGYNKVGPGYGPGEGAPEQEKSRGGYSSGFRDSVPIQGITLEEVSEIIGRDLSGFPAPPGEEPPA
|
| biopax3:standardName |
Nuclear factor of activated T-cells, cytoplasmic 4
|