| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + glycine = S- adenosyl-L-homocysteine + sarcosine. SUBUNIT: Homotetramer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Abundant in liver. DISEASE: Defects in GNMT are the cause of glycine N- methyltransferase deficiency (GNMT deficiency) [MIM:606664]; also known as hypermethioninemia. The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases. SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. GENE SYNONYMS:GNMT. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 295 AA; 32742 MW; 34F4546136FD27ED CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:4415,
urn:biopax:RelationshipXref:NCBI GENE_27232,
urn:biopax:RelationshipXref:REFSEQ_NP_061833,
urn:biopax:UnificationXref:UNIPROT_Q14749,
urn:biopax:UnificationXref:UNIPROT_Q5T8W2,
urn:biopax:UnificationXref:UNIPROT_Q9NNZ1,
urn:biopax:UnificationXref:UNIPROT_Q9NS24
|
| biopax3:displayName |
GNMT_HUMAN
|
| biopax3:name |
2.1.1.20,
GNMT
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MVDSVYRTRSLGVAAEGLPDQYADGEAARVWQLYIGDTRSRTAEYKAWLLGLLRQHGCQRVLDVACGTGVDSIMLVEEGFSVTSVDASDKMLKYALKERWNRRHEPAFDKWVIEEANWMTLDKDVPQSAEGGFDAVICLGNSFAHLPDCKGDQSEHRLALKNIASMVRAGGLLVIDHRNYDHILSTGCAPPGKNIYYKSDLTKDVTTSVLIVNNKAHMVTLDYTVQVPGAGQDGSPGLSKFRLSYYPHCLASFTELLQAAFGGKCQHSVLGDFKPYKPGQTYIPCYFIHVLKRTD
|
| biopax3:standardName |
Glycine N-methyltransferase
|