| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity). SUBUNIT: Binds in a sequence-specific manner to the 3'-UTR of some mRNAs. SUBCELLULAR LOCATION: Cytoplasm (Probable). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14671-1; Sequence=Displayed; Name=2; IsoId=Q14671-2; Sequence=VSP_017059, VSP_017060, VSP_017061; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested. INDUCTION: Strongly down-regulated in keratinocytes upon UVB irradiation. DOMAIN: The pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half doughnut. The number as well as the specific sequence of the repeats determine the specificity for target mRNAs. SIMILARITY: Contains 1 PUM-HD domain. SIMILARITY: Contains 8 pumilio repeats. SEQUENCE CAUTION: Sequence=BAA07895.3; Type=Erroneous initiation; GENE SYNONYMS:PUM1 KIAA0099 PUMH1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1186 AA; 126473 MW; E1E0D8B3B0181308 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:14957,
urn:biopax:RelationshipXref:NCBI GENE_9698,
urn:biopax:RelationshipXref:REFSEQ_NP_001018494,
urn:biopax:RelationshipXref:REFSEQ_NP_055491,
urn:biopax:UnificationXref:UNIPROT_A8K6W4,
urn:biopax:UnificationXref:UNIPROT_D3DPN3,
urn:biopax:UnificationXref:UNIPROT_Q14671,
urn:biopax:UnificationXref:UNIPROT_Q5VXY7,
urn:biopax:UnificationXref:UNIPROT_Q9HAN1
|
| biopax3:displayName |
PUM1_HUMAN
|
| biopax3:name |
HsPUM,
PUM1,
Pumilio-1
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:PUM1_HUMAN_1,
urn:biopax:ModificationFeature:PUM1_HUMAN_2,
urn:biopax:ModificationFeature:PUM1_HUMAN_3,
urn:biopax:ModificationFeature:PUM1_HUMAN_4,
urn:biopax:ModificationFeature:PUM1_HUMAN_5,
urn:biopax:ModificationFeature:PUM1_HUMAN_6,
urn:biopax:ModificationFeature:PUM1_HUMAN_7
|
| biopax3:organism | |
| biopax3:sequence |
MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNNSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSKDGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLGVSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPGNCQNSANEVDLLGPNQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSANQQTTPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPNNNLASSSFYGNNSLNSNSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLTPIGHSFYNGLSFSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII
|
| biopax3:standardName |
Pumilio homolog 1
|