| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.2 mM for uridine; KM=0.75 mM for adenosine; Note=Vmax for adenosine uptake is about the same for SLC29A1 and SLC29A2; SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein. Nucleus membrane; Multi-pass membrane protein. Note=Localized at the basolateral cell membrane in polarized MDCK cells. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long; IsoId=Q14542-1; Sequence=Displayed; Name=2; Synonyms=Short, HNP36; IsoId=Q14542-2; Sequence=VSP_040728, VSP_040729; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=3; IsoId=Q14542-3; Sequence=VSP_040730, VSP_040731; TISSUE SPECIFICITY: Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues. INDUCTION: By PDGF/platelet derived growth factor and fibroblast growth factor (FGF). SIMILARITY: Belongs to the SLC29A transporter family. SEQUENCE CAUTION: Sequence=CAA60380.1; Type=Erroneous translation; Note=Wrong choice of CDS; GENE SYNONYMS:SLC29A2 DER12 ENT2 HNP36. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 456 AA; 50113 MW; ABCBD244306708E1 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11004,
urn:biopax:RelationshipXref:NCBI GENE_3177,
urn:biopax:RelationshipXref:REFSEQ_NP_001523,
urn:biopax:UnificationXref:UNIPROT_B3KPY7,
urn:biopax:UnificationXref:UNIPROT_O43530,
urn:biopax:UnificationXref:UNIPROT_Q14542,
urn:biopax:UnificationXref:UNIPROT_Q52M84,
urn:biopax:UnificationXref:UNIPROT_Q96R00,
urn:biopax:UnificationXref:UNIPROT_Q9UPE0
|
| biopax3:displayName |
S29A2_HUMAN
|
| biopax3:name |
36 kDa nucleolar protein HNP36,
Delayed-early response protein 12,
Equilibrative NBMPR-insensitive nucleoside transporter,
Equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter,
Hydrophobic nucleolar protein, 36 kDa,
Nucleoside transporter, ei-type,
SLC29A2,
Solute carrier family 29 member 2
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MARGDAPRDSYHLVGISFFILGLGTLLPWNFFITAIPYFQARLAGAGNSTARILSTNHTGPEDAFNFNNWVTLLSQLPLLLFTLLNSFLYQCVPETVRILGSLLAILLLFALTAALVKVDMSPGPFFSITMASVCFINSFSAVLQGSLFGQLGTMPSTYSTLFLSGQGLAGIFAALAMLLSMASGVDAETSALGYFITPCVGILMSIVCYLSLPHLKFARYYLANKSSQAQAQELETKAELLQSDENGIPSSPQKVALTLDLDLEKEPESEPDEPQKPGKPSVFTVFQKIWLTALCLVLVFTVTLSVFPAITAMVTSSTSPGKWSQFFNPICCFLLFNIMDWLGRSLTSYFLWPDEDSRLLPLLVCLRFLFVPLFMLCHVPQRSRLPILFPQDAYFITFMLLFAVSNGYLVSLTMCLAPRQVLPHEREVAGALMTFFLALGLSCGASLSFLFKALL
|
| biopax3:standardName |
Equilibrative nucleoside transporter 2
|