| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). SUBUNIT: Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, growth cone (By similarity). Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14195-1; Sequence=Displayed; Name=LCRMP-4; IsoId=Q14195-2; Sequence=VSP_042546; TISSUE SPECIFICITY: Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord. PTM: Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3. SIMILARITY: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. CAUTION: Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure. GENE SYNONYMS:DPYSL3 CRMP4 DRP3 ULIP ULIP1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 570 AA; 61963 MW; 9D6AFE86CBB33AD5 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:3015,
urn:biopax:RelationshipXref:NCBI GENE_1809,
urn:biopax:RelationshipXref:REFSEQ_NP_001184223,
urn:biopax:RelationshipXref:REFSEQ_NP_001378,
urn:biopax:UnificationXref:UNIPROT_B3SXQ8,
urn:biopax:UnificationXref:UNIPROT_Q14195,
urn:biopax:UnificationXref:UNIPROT_Q93012
|
| biopax3:displayName |
DPYL3_HUMAN
|
| biopax3:name |
CRMP-4,
Collapsin response mediator protein 4,
DPYSL3,
DRP-3,
ULIP-1,
Unc-33-like phosphoprotein 1
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:DPYL3_HUMAN_1,
urn:biopax:ModificationFeature:DPYL3_HUMAN_2,
urn:biopax:ModificationFeature:DPYL3_HUMAN_3,
urn:biopax:ModificationFeature:DPYL3_HUMAN_4,
urn:biopax:ModificationFeature:DPYL3_HUMAN_5,
urn:biopax:ModificationFeature:DPYL3_HUMAN_6,
urn:biopax:ModificationFeature:DPYL3_HUMAN_7
|
| biopax3:organism | |
| biopax3:sequence |
MSYQGKKNIPRITSDRLLIKGGRIVNDDQSFYADIYMEDGLIKQIGDNLIVPGGVKTIEANGKMVIPGGIDVHTHFQMPYKGMTTVDDFFQGTKAALAGGTTMIIDHVVPEPESSLTEAYEKWREWADGKSCCDYALHVDITHWNDSVKQEVQNLIKDKGVNSFMVYMAYKDLYQVSNTELYEIFTCLGELGAIAQVHAENGDIIAQEQTRMLEMGITGPEGHVLSRPEELEAEAVFRAITIASQTNCPLYVTKVMSKSAADLISQARKKGNVVFGEPITASLGIDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYINSLLASGDLQLSGSAHCTFSTAQKAIGKDNFTAIPEGTNGVEERMSVIWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRISVGSDSDLVIWDPDAVKIVSAKNHQSAAEYNIFEGMELRGAPLVVICQGKIMLEDGNLHVTQGAGRFIPCSPFSDYVYKRIKARRKMADLHAVPRGMYDGPVFDLTTTPKGGTPAGSARGSPTRPNPPVRNLHQSGFSLSGTQVDEGVRSASKRIVAPPGGRSNITSLS
|
| biopax3:standardName |
Dihydropyrimidinase-related protein 3
|