| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. CATALYTIC ACTIVITY: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate. COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity). ENZYME REGULATION: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+). SUBUNIT: Homodimer (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist; Name=PDE1C2; Synonyms=HCam-3A; IsoId=Q14123-1; Sequence=Displayed; Name=PDE1C1; Synonyms=HCam-3B; IsoId=Q14123-2; Sequence=VSP_004552, VSP_004553; TISSUE SPECIFICITY: Expressed in several tissues, including brain and heart. SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. GENE SYNONYMS:PDE1C. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 709 AA; 80760 MW; 77133D4DDBE5F7C0 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:8776,
urn:biopax:RelationshipXref:NCBI GENE_5137,
urn:biopax:RelationshipXref:REFSEQ_NP_001177985,
urn:biopax:RelationshipXref:REFSEQ_NP_001177986,
urn:biopax:RelationshipXref:REFSEQ_NP_001177987,
urn:biopax:RelationshipXref:REFSEQ_NP_001177988,
urn:biopax:RelationshipXref:REFSEQ_NP_005011,
urn:biopax:UnificationXref:UNIPROT_B3KPC6,
urn:biopax:UnificationXref:UNIPROT_Q14123,
urn:biopax:UnificationXref:UNIPROT_Q14124
|
| biopax3:displayName |
PDE1C_HUMAN
|
| biopax3:name |
3.1.4.17,
Cam-PDE 1C,
PDE1C,
hCam-3
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPLRHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK
|
| biopax3:standardName |
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
|