| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters. SUBUNIT: Interacts with TBP and JUN (By similarity). Part of the nascent polypeptide-associated complex (NAC), consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent polypeptide chains. Interacts with ASFV protein H339R. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also found in nucleus. TISSUE SPECIFICITY: Ubiquitously expressed. PTM: Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-159 by GSK3B may promote proteasome mediated degradation (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. ALLERGEN: Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations. SIMILARITY: Belongs to the NAC-alpha family. SIMILARITY: Contains 1 NAC-A/B (NAC-alpha/beta) domain. SIMILARITY: Contains 1 UBA domain. SEQUENCE CAUTION: Sequence=AAV83778.1; Type=Erroneous initiation; GENE SYNONYMS:NACA. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 215 AA; 23384 MW; 05DC563A8BEF307C CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:7629,
urn:biopax:RelationshipXref:NCBI GENE_4666,
urn:biopax:RelationshipXref:REFSEQ_NP_001106673,
urn:biopax:RelationshipXref:REFSEQ_NP_001106674,
urn:biopax:UnificationXref:UNIPROT_Q13765,
urn:biopax:UnificationXref:UNIPROT_Q3KQV4,
urn:biopax:UnificationXref:UNIPROT_Q53A18,
urn:biopax:UnificationXref:UNIPROT_Q53G46
|
| biopax3:displayName |
NACA_HUMAN
|
| biopax3:name |
Alpha-NAC,
Hom s 2,
NAC-alpha,
NACA
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:NACA_HUMAN_1,
urn:biopax:ModificationFeature:NACA_HUMAN_2,
urn:biopax:ModificationFeature:NACA_HUMAN_3,
urn:biopax:ModificationFeature:NACA_HUMAN_4,
urn:biopax:ModificationFeature:NACA_HUMAN_5,
urn:biopax:ModificationFeature:NACA_HUMAN_6,
urn:biopax:ModificationFeature:NACA_HUMAN_7,
urn:biopax:ModificationFeature:NACA_HUMAN_8,
urn:biopax:ModificationFeature:NACA_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MPGEATETVPATEQELPQPQAETGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIRKSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLSQQAQLAAAEKFKVQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM
|
| biopax3:standardName |
Nascent polypeptide-associated complex subunit alpha
|