| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. SUBUNIT: Associates through its SH2 domain with ligand-activated receptors for stem cell factor (KIT) and erythropoietin (EPOR). Also forms a stable complex with the Bcr-Abl oncoprotein. GRAP is associated with the Ras guanine nucleotide exchange factor SOS1, primarily through its N-terminal SH3 domain. Interacts with phosphorylated LAT upon TCR activation. Interacts with SHB. SIMILARITY: Belongs to the GRB2/sem-5/DRK family. SIMILARITY: Contains 1 SH2 domain. SIMILARITY: Contains 2 SH3 domains. GENE SYNONYMS:GRAP. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 217 AA; 25337 MW; 09FEC2F3BAC0FAF8 CRC64;
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| biopax3:xref | |
| biopax3:displayName |
GRAP_HUMAN
|
| biopax3:name |
GRAP
|
| biopax3:organism | |
| biopax3:sequence |
MESVALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYIRVKPHPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREASGKYFLWEEKFNSLNELVDFYRTTTIAKKRQIFLRDEEPLLKSPGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGRSCGRVGFFPRSYVQPVHL
|
| biopax3:standardName |
GRB2-related adapter protein
|