Linked Life Data

Q13555

Source:http://identifiers.org/uniprot/Q13555

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
biopax3:comment
FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow- twitch muscles, is involved in regulation of sarcoplamic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr- 287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. SUBUNIT: CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of the other. SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (Probable). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=10; Name=1; IsoId=Q13555-1; Sequence=Displayed; Name=2; IsoId=Q13555-2; Sequence=VSP_013349; Name=3; IsoId=Q13555-3; Sequence=VSP_013350; Name=4; IsoId=Q13555-4; Sequence=VSP_004778; Name=5; IsoId=Q13555-5; Sequence=VSP_032699, VSP_032700, VSP_004778; Name=6; IsoId=Q13555-6; Sequence=VSP_032699, VSP_035456; Name=7; Synonyms=gamma F; IsoId=Q13555-7; Sequence=VSP_013350, VSP_035456; Name=8; Synonyms=gamma E; IsoId=Q13555-8; Sequence=VSP_013349, VSP_035456; Name=9; Synonyms=gamma D; IsoId=Q13555-9; Sequence=VSP_013349, VSP_036027, VSP_035456; Name=10; IsoId=Q13555-10; Sequence=VSP_013350, VSP_004778; TISSUE SPECIFICITY: Expressed in skeletal muscle. INDUCTION: Activity is induced in skeletal muscle during exercise. DOMAIN: The CAMK2 protein kinases contain a unique C-terminal subunit association domain responsible for oligomerization. PTM: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAB61379.1; Type=Erroneous initiation; Note=Translation N-terminally extended; GENE SYNONYMS:CAMK2G CAMK CAMK-II CAMKG. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 558 AA; 62609 MW; 38D4112C2FDBD44C CRC64;
biopax3:xref
biopax3:displayName
KCC2G_HUMAN
biopax3:name
2.7.11.17, CAMK2G, CaM kinase II subunit gamma, CaMK-II subunit gamma
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biopax3:organism
biopax3:sequence
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKARSPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
biopax3:standardName
Calcium/calmodulin-dependent protein kinase type II subunit gamma