| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. SUBUNIT: Nonphosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) or mTORC1 phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. Interacts with RPTOR. PTM: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser- 65 and Thr-70 is regulated by mTORC1. Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the eIF4E-binding protein family. GENE SYNONYMS:EIF4EBP1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 118 AA; 12580 MW; 1682A6BA74132966 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:3288,
urn:biopax:RelationshipXref:NCBI GENE_1978,
urn:biopax:RelationshipXref:REFSEQ_NP_004086,
urn:biopax:UnificationXref:UNIPROT_B2R502,
urn:biopax:UnificationXref:UNIPROT_D3DSW8,
urn:biopax:UnificationXref:UNIPROT_Q13541,
urn:biopax:UnificationXref:UNIPROT_Q6IBN3
|
| biopax3:displayName |
4EBP1_HUMAN
|
| biopax3:name |
4E-BP1,
EIF4EBP1,
PHAS-I,
Phosphorylated heat- and acid-stable protein regulated by insulin 1,
eIF4E-binding protein 1
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:4EBP1_HUMAN_1,
urn:biopax:ModificationFeature:4EBP1_HUMAN_10,
urn:biopax:ModificationFeature:4EBP1_HUMAN_11,
urn:biopax:ModificationFeature:4EBP1_HUMAN_12,
urn:biopax:ModificationFeature:4EBP1_HUMAN_13,
urn:biopax:ModificationFeature:4EBP1_HUMAN_14,
urn:biopax:ModificationFeature:4EBP1_HUMAN_15,
urn:biopax:ModificationFeature:4EBP1_HUMAN_16,
urn:biopax:ModificationFeature:4EBP1_HUMAN_17,
urn:biopax:ModificationFeature:4EBP1_HUMAN_18,
urn:biopax:ModificationFeature:4EBP1_HUMAN_19,
urn:biopax:ModificationFeature:4EBP1_HUMAN_2,
urn:biopax:ModificationFeature:4EBP1_HUMAN_20,
urn:biopax:ModificationFeature:4EBP1_HUMAN_21,
urn:biopax:ModificationFeature:4EBP1_HUMAN_3,
urn:biopax:ModificationFeature:4EBP1_HUMAN_4,
urn:biopax:ModificationFeature:4EBP1_HUMAN_5,
urn:biopax:ModificationFeature:4EBP1_HUMAN_6,
urn:biopax:ModificationFeature:4EBP1_HUMAN_7,
urn:biopax:ModificationFeature:4EBP1_HUMAN_8,
urn:biopax:ModificationFeature:4EBP1_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MSGGSSCSQTPSRAIPATRRVVLGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVTKTPPRDLPTIPGVTSPSSDEPPMEASQSHLRNSPEDKRAGGEESQFEMDI
|
| biopax3:standardName |
Eukaryotic translation initiation factor 4E-binding protein 1
|