| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). SUBUNIT: Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11. Interacts with HCK. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q13480-1; Sequence=Displayed; Name=2; IsoId=Q13480-2; Sequence=VSP_017137; Note=Phosphorylated on Ser-547; PTM: Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling. SIMILARITY: Belongs to the GAB family. SIMILARITY: Contains 1 PH domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gab1/"; GENE SYNONYMS:GAB1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 694 AA; 76616 MW; E0FAC78772B6677B CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:4066,
urn:biopax:RelationshipXref:NCBI GENE_2549,
urn:biopax:RelationshipXref:REFSEQ_NP_002030,
urn:biopax:RelationshipXref:REFSEQ_NP_997006,
urn:biopax:UnificationXref:UNIPROT_A8K152,
urn:biopax:UnificationXref:UNIPROT_Q13480,
urn:biopax:UnificationXref:UNIPROT_Q4W5G2,
urn:biopax:UnificationXref:UNIPROT_Q6P1W2
|
| biopax3:displayName |
GAB1_HUMAN
|
| biopax3:name |
GAB1,
GRB2-associated binder 1,
Growth factor receptor bound protein 2-associated protein 1
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:GAB1_HUMAN_1,
urn:biopax:ModificationFeature:GAB1_HUMAN_2,
urn:biopax:ModificationFeature:GAB1_HUMAN_3,
urn:biopax:ModificationFeature:GAB1_HUMAN_4,
urn:biopax:ModificationFeature:GAB1_HUMAN_5,
urn:biopax:ModificationFeature:GAB1_HUMAN_6,
urn:biopax:ModificationFeature:GAB1_HUMAN_7,
urn:biopax:ModificationFeature:GAB1_HUMAN_8
|
| biopax3:organism | |
| biopax3:sequence |
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
|
| biopax3:standardName |
GRB2-associated-binding protein 1
|