| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Membrane-anchored forms may play a role in cellular adhesion. FUNCTION: Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. SUBUNIT: Interacts with MUC16. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus. SUBCELLULAR LOCATION: Megakaryocyte-potentiating factor: Secreted. SUBCELLULAR LOCATION: Isoform 3: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q13421-1; Sequence=Displayed; Note=Minor form; Name=2; IsoId=Q13421-3; Sequence=VSP_021059; Note=Major form; Name=3; Synonyms=SMRP; IsoId=Q13421-2; Sequence=VSP_021059, VSP_021060; Note=Soluble form found in the sera from patients with ovarian carcinoma; Name=4; IsoId=Q13421-4; Sequence=VSP_021058, VSP_021059; TISSUE SPECIFICITY: Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). PTM: Both MPF and the cleaved form of mesothelin are N- glycosylated. PTM: Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. DISEASE: Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. SIMILARITY: Belongs to the mesothelin family. GENE SYNONYMS:MSLN MPF. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 630 AA; 68986 MW; FA17E3609B6CC9CA CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:7371,
urn:biopax:RelationshipXref:NCBI GENE_10232,
urn:biopax:RelationshipXref:REFSEQ_NP_001170826,
urn:biopax:RelationshipXref:REFSEQ_NP_005814,
urn:biopax:RelationshipXref:REFSEQ_NP_037536,
urn:biopax:UnificationXref:UNIPROT_D3DU65,
urn:biopax:UnificationXref:UNIPROT_Q13421,
urn:biopax:UnificationXref:UNIPROT_Q14859,
urn:biopax:UnificationXref:UNIPROT_Q4VQD5,
urn:biopax:UnificationXref:UNIPROT_Q96GR6,
urn:biopax:UnificationXref:UNIPROT_Q96KJ5,
urn:biopax:UnificationXref:UNIPROT_Q9BR17,
urn:biopax:UnificationXref:UNIPROT_Q9BTR2,
urn:biopax:UnificationXref:UNIPROT_Q9UCB2,
urn:biopax:UnificationXref:UNIPROT_Q9UK57
|
| biopax3:displayName |
MSLN_HUMAN
|
| biopax3:name |
CAK1 antigen,
MPF,
MSLN,
Megakaryocyte-potentiating factor,
Mesothelin, cleaved form,
Pre-pro-megakaryocyte-potentiating factor
|
| biopax3:organism | |
| biopax3:sequence |
MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGTPCLLGPGPVLTVLALLLASTLA
|
| biopax3:standardName |
Mesothelin
|