| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). CATALYTIC ACTIVITY: A phosphatidylcholine + H(2)O = choline + a phosphatidate. ENZYME REGULATION: Stimulated by phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate, activated by the phosphokinase C-alpha, by the ADP-ribosylation factor-1 (ARF-1), and to a lesser extent by GTP-binding proteins: RHO A, RAC-1 and CDC42. Inhibited by oleate. SUBUNIT: Interacts with PIP5K1B. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region (By similarity). Endoplasmic reticulum membrane; Lipid-anchor; Cytoplasmic side (By similarity). Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side (By similarity). Late endosome membrane; Lipid-anchor; Cytoplasmic side (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=PLD1A; IsoId=Q13393-1; Sequence=Displayed; Name=PLD1B; IsoId=Q13393-2; Sequence=VSP_005020; Name=PLD1C; IsoId=Q13393-3; Sequence=VSP_005018, VSP_005019; Name=PLD1D; IsoId=Q13393-4; Sequence=VSP_005021, VSP_005022; TISSUE SPECIFICITY: Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine. SIMILARITY: Belongs to the phospholipase D family. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 2 PLD phosphodiesterase domains. SIMILARITY: Contains 1 PX (phox homology) domain. WEB RESOURCE: Name=Wikipedia; Note=Phospholipase D entry; URL="http://en.wikipedia.org/wiki/Phospholipase_D"; GENE SYNONYMS:PLD1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 1074 AA; 124184 MW; 734F285790A0BF7A CRC64;
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| biopax3:xref | |
| biopax3:displayName |
PLD1_HUMAN
|
| biopax3:name |
3.1.4.4,
Choline phosphatase 1,
PLD 1,
PLD1,
Phosphatidylcholine-hydrolyzing phospholipase D1,
hPLD1
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MSLKNEPRVNTSALQKIAADMSNIIENLDTRELHFEGEEVDYDVSPSDPKIQEVYIPFSAIYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTTRVPSINLYTIELTHGEFKWQVKRKFKHFQEFHRELLKYKAFIRIPIPTRRHTFRRQNVREEPREMPSLPRSSENMIREEQFLGRRKQLEDYLTKILKMPMYRNYHATTEFLDISQLSFIHDLGPKGIEGMIMKRSGGHRIPGLNCCGQGRACYRWSKRWLIVKDSFLLYMKPDSGAIAFVLLVDKEFKIKVGKKETETKYGIRIDNLSRTLILKCNSYRHARWWGGAIEEFIQKHGTNFLKDHRFGSYAAIQENALAKWYVNAKGYFEDVANAMEEANEEIFITDWWLSPEIFLKRPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYTKRTLMRLHPNIKVMRHPDHVSSTVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGPSLGSLPPAAMESMESLRLKDKNEPVQNLPIQKSIDDVDSKLKGIGKPRKFSKFSLYKQLHRHHLHDADSISSIDSTSSYFNHYRSHHNLIHGLKPHFKLFHPSSESEQGLTRPHADTGSIRSLQTGVGELHGETRFWHGKDYCNFVFKDWVQLDKPFADFIDRYSTPRMPWHDIASAVHGKAARDVARHFIQRWNFTKIMKSKYRSLSYPFLLPKSQTTAHELRYQVPGSVHANVQLLRSAADWSAGIKYHEESIHAAYVHVIENSRHYIYIENQFFISCADDKVVFNKIGDAIAQRILKAHRENQKYRVYVVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGENSILGQLKAELGNQWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIGSANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARGLRLQCFRVVLGYLDDPSEDIQDPVSDKFFKEVWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPVLAKEDPIRAEEELKKIRGFLVQFPFYFLSEESLLPSVGTKEAIVPMEVWT
|
| biopax3:standardName |
Phospholipase D1
|