| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. SUBUNIT: Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=SRP40-1; IsoId=Q13243-1; Sequence=Displayed; Name=SRP40-2; IsoId=Q13243-2; Sequence=VSP_005864, VSP_005865; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=SRP40-3; IsoId=Q13243-4; Sequence=Not described; Name=SRP40-4; IsoId=Q13243-3; Sequence=VSP_005863; Note=No experimental confirmation available; PTM: Extensively phosphorylated on serine residues in the RS domain (By similarity). SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains. SEQUENCE CAUTION: Sequence=AAC39543.1; Type=Frameshift; Positions=113, 140; GENE SYNONYMS:SRSF5 HRS SFRS5 SRP40. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 272 AA; 31264 MW; F13AD79845ECBB16 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:10787,
urn:biopax:RelationshipXref:NCBI GENE_6430,
urn:biopax:RelationshipXref:REFSEQ_NP_001034554,
urn:biopax:RelationshipXref:REFSEQ_NP_008856,
urn:biopax:UnificationXref:UNIPROT_O14797,
urn:biopax:UnificationXref:UNIPROT_Q13243,
urn:biopax:UnificationXref:UNIPROT_Q16662,
urn:biopax:UnificationXref:UNIPROT_Q49AD6,
urn:biopax:UnificationXref:UNIPROT_Q6FGE0
|
| biopax3:displayName |
SRSF5_HUMAN
|
| biopax3:name |
Delayed-early protein HRS,
Pre-mRNA-splicing factor SRP40,
SRSF5,
Splicing factor, arginine/serine-rich 5
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:SRSF5_HUMAN_1,
urn:biopax:ModificationFeature:SRSF5_HUMAN_10,
urn:biopax:ModificationFeature:SRSF5_HUMAN_11,
urn:biopax:ModificationFeature:SRSF5_HUMAN_12,
urn:biopax:ModificationFeature:SRSF5_HUMAN_13,
urn:biopax:ModificationFeature:SRSF5_HUMAN_2,
urn:biopax:ModificationFeature:SRSF5_HUMAN_3,
urn:biopax:ModificationFeature:SRSF5_HUMAN_4,
urn:biopax:ModificationFeature:SRSF5_HUMAN_5,
urn:biopax:ModificationFeature:SRSF5_HUMAN_6,
urn:biopax:ModificationFeature:SRSF5_HUMAN_7,
urn:biopax:ModificationFeature:SRSF5_HUMAN_8,
urn:biopax:ModificationFeature:SRSF5_HUMAN_9
|
| biopax3:organism | |
| biopax3:sequence |
MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGKELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGRKIKLIEGSKRHSRSRSRSRSRTRSSSRSRSRSRSRSRKSYSRSRSRSRSRSRSKSRSVSRSPVPEKSQKRGSSSRSKSPASVDRQRSRSRSRSRSVDSGN
|
| biopax3:standardName |
Serine/arginine-rich splicing factor 5
|