| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May play a role in ruffle formation and actin cytoskeleton organization. Seems to negatively regulate constitutive secretion (By similarity). SUBUNIT: Part of a complex consisting of CALCOCO2, TAX1BP1 and MYO6. Interacts with GEMIN4. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Golgi apparatus. Cytoplasm, cytoskeleton. Note=According to PubMed:7540613, localizes to nuclear dots. According to PubMed:9230084 and PubMed:12869526, it is not a nuclear dot- associated protein but localizes predominantly in the cytoplasm with a coarse-grained distribution preferentially close to the nucleus. TISSUE SPECIFICITY: Expressed in all tissues tested with highest expression in skeletal muscle and lowest in brain. MISCELLANEOUS: According to PubMed:7540613, HSV-1 infection removes CALCOCO2 from the nucleus, however, it remains faintly in areas shown to be domains, containing splicing components. Treatment with IFNB1/IFN-beta and IFNG/IFN-gamma show an increase in number and size of CALCOCO2-specific dots and partial redistribution to the cytoplasm. According to PubMed:9230084, IFNG/IFN-gamma increases gene expression only slightly and IFNB does not increase expression. GENE SYNONYMS:CALCOCO2 NDP52. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 446 AA; 52254 MW; 609B121DA1A9DCB8 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:29912,
urn:biopax:RelationshipXref:NCBI GENE_10241,
urn:biopax:RelationshipXref:REFSEQ_NP_005822,
urn:biopax:UnificationXref:UNIPROT_B2RBT0,
urn:biopax:UnificationXref:UNIPROT_Q13137,
urn:biopax:UnificationXref:UNIPROT_Q53FQ5,
urn:biopax:UnificationXref:UNIPROT_Q53HB5,
urn:biopax:UnificationXref:UNIPROT_Q6IBN9,
urn:biopax:UnificationXref:UNIPROT_Q9BTF7
|
| biopax3:displayName |
CACO2_HUMAN
|
| biopax3:name |
Antigen nuclear dot 52 kDa protein,
CALCOCO2,
Nuclear domain 10 protein 52,
Nuclear domain 10 protein NDP52,
Nuclear dot protein 52
|
| biopax3:organism | |
| biopax3:sequence |
MEETIKDPPTSAVLLDHCHFSQVIFNSVEKFYIPGGDVTCHYTFTQHFIPRRKDWIGIFRVGWKTTREYYTFMWVTLPIDLNNKSAKQQEVQFKAYYLPKDDEYYQFCYVDEDGVVRGASIPFQFRPENEEDILVVTTQGEVEEIEQHNKELCKENQELKDSCISLQKQNSDMQAELQKKQEELETLQSINKKLELKVKEQKDYWETELLQLKEQNQKMSSENEKMGIRVDQLQAQLSTQEKEMEKLVQGDQDKTEQLEQLKKENDHLFLSLTEQRKDQKKLEQTVEQMKQNETTAMKKQQELMDENFDLSKRLSENEIICNALQRQKERLEGENDLLKRENSRLLSYMGLDFNSLPYQVPTSDEGGARQNPGLAYGNPYSGIQESSSPSPLSIKKCPICKADDICDHTLEQQQMQPLCFNCPICDKIFPATEKQIFEDHVFCHSL
|
| biopax3:standardName |
Calcium-binding and coiled-coil domain-containing protein 2
|