| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: The APC/C is composed of at least 12 subunits. Interacts with PPP5C and CDC20. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q13042-1; Sequence=Displayed; Name=2; IsoId=Q13042-2; Sequence=VSP_008427; Note=No experimental confirmation available; Name=3; IsoId=Q13042-3; Sequence=VSP_008427, VSP_008428; PTM: Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis. SIMILARITY: Belongs to the APC6/CDC16 family. SIMILARITY: Contains 7 TPR repeats. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc16/"; GENE SYNONYMS:CDC16 ANAPC6. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 620 AA; 71656 MW; A9C4F24615DF17EB CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:1720,
urn:biopax:RelationshipXref:NCBI GENE_8881,
urn:biopax:RelationshipXref:REFSEQ_NP_001072113,
urn:biopax:RelationshipXref:REFSEQ_NP_003894,
urn:biopax:UnificationXref:UNIPROT_A2A365,
urn:biopax:UnificationXref:UNIPROT_Q13042,
urn:biopax:UnificationXref:UNIPROT_Q5T8C8,
urn:biopax:UnificationXref:UNIPROT_Q96AE6,
urn:biopax:UnificationXref:UNIPROT_Q9Y564
|
| biopax3:displayName |
CDC16_HUMAN
|
| biopax3:name |
APC6,
Anaphase-promoting complex subunit 6,
CDC16,
CDC16 homolog,
CDC16Hs,
Cyclosome subunit 6
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MNLERLRKRVRQYLDQQQYQSALFWADKVASLSREEPQDIYWLAQCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDVLDMEEPINKRLFEKYLKDESGFKDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLDVYCFEAFDLLTSHHMLTAQEEKELLESLPLSKLCNEEQELLRFLFENKLKKYNKPSETVIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSVVMEKDPFHASCLPVHIGTLVELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYGPAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNNLGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGLRRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFREFEVEKQTAEETGLTPLETSRKTPDSRPSLEETFEIEMNESDMMLETSMSDHST
|
| biopax3:standardName |
Cell division cycle protein 16 homolog
|