| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1- mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. SUBUNIT: Homodimer. Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts (via N-terminus) with RARS (via N-terminus). Interacts (via C-terminus) with SMURF2. Interacts (via N-terminus) with HSP90B1/gp96 (via C- terminus). Interacts with PSMA7. SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle (By similarity). Secreted (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). Note=Enriched in secretory vesicles of pancreatic alpha cells and secreted from the pancreas in response to low glucose levels (By similarity). Also secreted in response to hypoxia and both apoptotic and necrotic cell death. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q12904-1; Sequence=Displayed; Name=2; IsoId=Q12904-2; Sequence=VSP_042197; PTM: Cleaved by caspase-7 in response to apoptosis to produce EMAP-II. DISEASE: Defects in AIMP1 are the cause of leukodystrophy hypomyelinating type 3 (HLD3) [MIM:260600]. A severe autosomal recessive hypomyelinating leukodystrophy characterized by early infantile onset of global developmental delay, lack of development, lack of speech acquisition, and peripheral spasticity associated with decreased myelination in the central nervous system. SIMILARITY: Contains 1 tRNA-binding domain. GENE SYNONYMS:AIMP1 EMAP2 SCYE1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 312 AA; 34353 MW; 5F0BF73E58810C60 CRC64;
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| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:10648,
urn:biopax:RelationshipXref:NCBI GENE_9255,
urn:biopax:RelationshipXref:REFSEQ_NP_001135887,
urn:biopax:RelationshipXref:REFSEQ_NP_001135888,
urn:biopax:RelationshipXref:REFSEQ_NP_004748,
urn:biopax:UnificationXref:UNIPROT_B3KTR2,
urn:biopax:UnificationXref:UNIPROT_B4E1S7,
urn:biopax:UnificationXref:UNIPROT_Q12904,
urn:biopax:UnificationXref:UNIPROT_Q6FG28,
urn:biopax:UnificationXref:UNIPROT_Q96CQ9
|
| biopax3:displayName |
AIMP1_HUMAN
|
| biopax3:name |
AIMP1,
EMAP-2,
EMAP-II,
Endothelial monocyte-activating polypeptide 2,
Endothelial monocyte-activating polypeptide II,
Multisynthase complex auxiliary component p43,
Small inducible cytokine subfamily E member 1
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MANNDAVLKRLEQKGAEADQIIEYLKQQVSLLKEKAILQATLREEKKLRVENAKLKKEIEELKQELIQAEIQNGVKQIPFPSGTPLHANSMVSENVIQSTAVTTVSSGTKEQIKGGTGDEKKAKEKIEKKGEKKEKKQQSIAGSADSKPIDVSRLDLRIGCIITARKHPDADSLYVEEVDVGEIAPRTVVSGLVNHVPLEQMQNRMVILLCNLKPAKMRGVLSQAMVMCASSPEKIEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQIQPDLHTNDECVATYKGVPFEVKGKGVCRAQTMSNSGIK
|
| biopax3:standardName |
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
|