| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre- mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity). Could play an important role in development and differentiation in the spleen and thymus. SUBUNIT: Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts (via RS domain) with PHF5A (via N-terminus) (By similarity). SUBCELLULAR LOCATION: Nucleus (Potential). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q09167-1; Sequence=Displayed; Name=2; Synonyms=HRR-LF; IsoId=Q09167-2; Sequence=VSP_005867, VSP_005868; TISSUE SPECIFICITY: Highly expressed in spleen and thymus. INDUCTION: By insulin and hepatectomy. PTM: Extensively phosphorylated on serine residues in the RS domain (By similarity). SIMILARITY: Belongs to the splicing factor SR family. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains. GENE SYNONYMS:Srsf5 Cl-4 Hrs Sfrs5. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 269 AA; 30891 MW; 0FC90628B64DE845 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:NCBI GENE_29667,
urn:biopax:RelationshipXref:RAT GENOME DATABASE_3664,
urn:biopax:RelationshipXref:REFSEQ_NP_001182434,
urn:biopax:RelationshipXref:REFSEQ_NP_001182435,
urn:biopax:RelationshipXref:REFSEQ_NP_062130,
urn:biopax:UnificationXref:UNIPROT_O35335,
urn:biopax:UnificationXref:UNIPROT_Q09167
|
| biopax3:displayName |
SRSF5_RAT
|
| biopax3:name |
Delayed-early protein HRS,
Insulin-induced growth response protein CL-4,
Pre-mRNA-splicing factor SRP40,
Splicing factor, arginine/serine-rich 5,
Srsf5
|
| biopax3:entityFeature |
urn:biopax:ModificationFeature:SRSF5_RAT_1,
urn:biopax:ModificationFeature:SRSF5_RAT_10,
urn:biopax:ModificationFeature:SRSF5_RAT_11,
urn:biopax:ModificationFeature:SRSF5_RAT_12,
urn:biopax:ModificationFeature:SRSF5_RAT_13,
urn:biopax:ModificationFeature:SRSF5_RAT_2,
urn:biopax:ModificationFeature:SRSF5_RAT_3,
urn:biopax:ModificationFeature:SRSF5_RAT_4,
urn:biopax:ModificationFeature:SRSF5_RAT_5,
urn:biopax:ModificationFeature:SRSF5_RAT_6,
urn:biopax:ModificationFeature:SRSF5_RAT_7,
urn:biopax:ModificationFeature:SRSF5_RAT_8,
urn:biopax:ModificationFeature:SRSF5_RAT_9
|
| biopax3:organism | |
| biopax3:sequence |
MSGCRVFIGRLNPAAREKDVERFFKGYGRIRDIDLKRGFGFVEFEDPRDADDAVYELDGKELCSERVTIEHARARSRGGRGRGRYSDRFSSRRPRNDRRNAPPVRTENRLIVENLSSRVSWQDLKDFMRQAGEVTFADAHRPKLNEGVVEFASYGDLKNAIEKLSGKEINGRKIKLIEGSKRHRSRSRSRSRTRSSSRSRSRSRSRRSKSYSRSRSRSRSRSKSRSGSRSPVPEKSQKRGSSSRSKSPASVDRQRSRSRSRSRSVDSGN
|
| biopax3:standardName |
Serine/arginine-rich splicing factor 5
|