| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. CATALYTIC ACTIVITY: NADPH + 2 quinone = NADP(+) + 2 semiquinone. SUBUNIT: Homotetramer. SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q08257-1; Sequence=Displayed; Name=2; IsoId=Q08257-2; Sequence=VSP_042927, VSP_042928; Note=No experimental confirmation available; TISSUE SPECIFICITY: Only very low amounts in the lens. SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. GENE SYNONYMS:CRYZ. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 329 AA; 35207 MW; 68C1828911486D4E CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:2419,
urn:biopax:RelationshipXref:NCBI GENE_1429,
urn:biopax:RelationshipXref:REFSEQ_NP_001123514,
urn:biopax:RelationshipXref:REFSEQ_NP_001123515,
urn:biopax:RelationshipXref:REFSEQ_NP_001128231,
urn:biopax:RelationshipXref:REFSEQ_NP_001880,
urn:biopax:UnificationXref:UNIPROT_D3DQ76,
urn:biopax:UnificationXref:UNIPROT_Q08257,
urn:biopax:UnificationXref:UNIPROT_Q53FT0,
urn:biopax:UnificationXref:UNIPROT_Q59EU7,
urn:biopax:UnificationXref:UNIPROT_Q5HYE7,
urn:biopax:UnificationXref:UNIPROT_Q6NSK9
|
| biopax3:displayName |
QOR_HUMAN
|
| biopax3:name |
1.6.5.5,
CRYZ,
NADPH:quinone reductase,
Zeta-crystallin
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL
|
| biopax3:standardName |
Quinone oxidoreductase
|