Q04637

FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. SUBUNIT: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with CIRBP and MIF4GD. Interacts with rotavirus A NSP3; in this interaction, NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis. Interacts with RBM4. ALTERNATIVE PRODUCTS: Event=Alternative splicing, Alternative initiation; Named isoforms=5; Name=A; IsoId=Q04637-1; Sequence=Displayed; Name=B; IsoId=Q04637-3; Sequence=VSP_018720; Note=Produced by alternative initiation at Met-41 of isoform A; Name=C; IsoId=Q04637-4; Sequence=VSP_018721; Note=Produced by alternative initiation at Met-88 of isoform A; Name=D; IsoId=Q04637-5; Sequence=VSP_018722; Note=Produced by alternative initiation at Met-165 of isoform A; Name=E; IsoId=Q04637-6; Sequence=VSP_018723; Note=Produced by alternative initiation at Met-197 of isoform A; PTM: Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1185 by PRKCA induces binding to MKNK1. PTM: Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription. DISEASE: Defects in EIF4G1 are the cause of Parkinson disease type 18 (PARK18) [MIM:614251]. An autosomal dominant, late-onset form of Parkinson disease. Parkinson disease is a complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. SIMILARITY: Belongs to the eIF4G family. SIMILARITY: Contains 1 MI domain. SIMILARITY: Contains 1 MIF4G domain. SIMILARITY: Contains 1 W2 domain. SEQUENCE CAUTION: Sequence=AAC78444.1; Type=Erroneous initiation; Sequence=AAC82471.1; Type=Erroneous initiation; Sequence=BAA02185.1; Type=Frameshift; Positions=Several; Sequence=BAD18554.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; GENE SYNONYMS:EIF4G1 EIF4F EIF4G EIF4GI. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 1599 AA; 175491 MW; 324088B60863DA34 CRC64;

IF4G1_HUMAN

urn:biopax:ModificationFeature:IF4G1_HUMAN_1, urn:biopax:ModificationFeature:IF4G1_HUMAN_10, urn:biopax:ModificationFeature:IF4G1_HUMAN_11, urn:biopax:ModificationFeature:IF4G1_HUMAN_12, urn:biopax:ModificationFeature:IF4G1_HUMAN_13, urn:biopax:ModificationFeature:IF4G1_HUMAN_14, urn:biopax:ModificationFeature:IF4G1_HUMAN_15, urn:biopax:ModificationFeature:IF4G1_HUMAN_16, urn:biopax:ModificationFeature:IF4G1_HUMAN_17, urn:biopax:ModificationFeature:IF4G1_HUMAN_2, urn:biopax:ModificationFeature:IF4G1_HUMAN_3, urn:biopax:ModificationFeature:IF4G1_HUMAN_4, urn:biopax:ModificationFeature:IF4G1_HUMAN_5, urn:biopax:ModificationFeature:IF4G1_HUMAN_6, urn:biopax:ModificationFeature:IF4G1_HUMAN_7, urn:biopax:ModificationFeature:IF4G1_HUMAN_8, urn:biopax:ModificationFeature:IF4G1_HUMAN_9

MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPSSAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTIRIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEESTPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHEPNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGGEELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGINCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVLMTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDSNNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRVVQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQPEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYEILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEILGLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN