| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. SUBUNIT: Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor. SUBCELLULAR LOCATION: Isoform 2: Secreted (Probable). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=uPAR1, GPI-anchored; IsoId=Q03405-1; Sequence=Displayed; Name=2; Synonyms=uPAR2, Secreted; IsoId=Q03405-2; Sequence=VSP_006715; Name=3; IsoId=Q03405-3; Sequence=VSP_006714; TISSUE SPECIFICITY: Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. SIMILARITY: Contains 3 UPAR/Ly6 domains. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/plaur/"; GENE SYNONYMS:PLAUR MO3 UPAR. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 335 AA; 36978 MW; AB1963EA3DC77171 CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:9053,
urn:biopax:RelationshipXref:NCBI GENE_5329,
urn:biopax:RelationshipXref:REFSEQ_NP_001005376,
urn:biopax:RelationshipXref:REFSEQ_NP_001005377,
urn:biopax:RelationshipXref:REFSEQ_NP_002650,
urn:biopax:UnificationXref:UNIPROT_A8K409,
urn:biopax:UnificationXref:UNIPROT_Q03405,
urn:biopax:UnificationXref:UNIPROT_Q12876,
urn:biopax:UnificationXref:UNIPROT_Q15845,
urn:biopax:UnificationXref:UNIPROT_Q16887,
urn:biopax:UnificationXref:UNIPROT_Q6IB52,
urn:biopax:UnificationXref:UNIPROT_Q9BWT0,
urn:biopax:UnificationXref:UNIPROT_Q9NYC8,
urn:biopax:UnificationXref:UNIPROT_Q9UD69,
urn:biopax:UnificationXref:UNIPROT_Q9UEA6,
urn:biopax:UnificationXref:UNIPROT_Q9UM92,
urn:biopax:UnificationXref:UNIPROT_Q9UMV0
|
| biopax3:displayName |
UPAR_HUMAN
|
| biopax3:name |
CD87,
Monocyte activation antigen Mo3,
PLAUR,
U-PAR,
uPAR
|
| biopax3:organism | |
| biopax3:sequence |
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
|
| biopax3:standardName |
Urokinase plasminogen activator surface receptor
|