Q03060

Source:http://identifiers.org/uniprot/Q03060

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Predicate	Object
rdf:type	biopax3:ProteinReference
biopax3:comment	FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity). SUBUNIT: Binds DNA as a dimer. Interacts with FHL5 (By similarity). Interacts with CDC34. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative promoter usage, Alternative splicing; Named isoforms=22; Name=1; Synonyms=CREM-BCEFGgammaHIbeta; IsoId=Q03060-5; Sequence=Displayed; Note=Produced by alternative promoter usage; Name=2; Synonyms=Beta, CREM-BCEFGHIbeta; IsoId=Q03060-1; Sequence=VSP_025037; Note=Produced by alternative splicing of isoform 1. Activator; Name=3; Synonyms=CREM-BCEFGIalpha, Tau; IsoId=Q03060-6; Sequence=VSP_025037, VSP_025038; Note=Produced by alternative splicing of isoform 1. Activator; Name=4; Synonyms=Alpha, CREM-BEFHIb, CREM-gamma; IsoId=Q03060-2; Sequence=VSP_000599, VSP_000600, VSP_025037, VSP_000601; Note=Produced by alternative splicing of isoform 1; Name=5; Synonyms=CREM-theta2tau-gamma, CREM-theta2EFGHIb; IsoId=Q03060-7; Sequence=VSP_025035, VSP_025036, VSP_025037; Note=Produced by alternative promoter usage. Activator; Name=6; Synonyms=CREM2alpha-a, IcergammaHIalpha, ICER1, ICERI; IsoId=Q03060-8; Sequence=VSP_026075, VSP_026078, VSP_025038; Note=Produced by alternative promoter usage. Repressor. Ref.3 (AAC19383) sequence is in conflict in positions: 7:D->E, 112:K->R; Name=7; Synonyms=CREM2alpha-b, IcerHIalpha, ICERIgamma; IsoId=Q03060-9; Sequence=VSP_026075, VSP_026078, VSP_025037, VSP_025038; Note=Produced by alternative splicing of isoform 6. Repressor; Name=8; Synonyms=CREM 2beta-a, IcergammaHIbeta, ICERII; IsoId=Q03060-10; Sequence=VSP_026075, VSP_026078; Note=Produced by alternative splicing of isoform 6. Repressor. Ref.2 (AAB03751) sequence is in conflict in position: 7:D->E; Name=9; Synonyms=CREM 2beta-b, IcerHIbeta, ICERIIgamma; IsoId=Q03060-11; Sequence=VSP_026075, VSP_026078, VSP_025037; Note=Produced by alternative splicing of isoform 6. Repressor; Name=10; Synonyms=CREMtheta1tau2beta, CREM-theta1EFGHIbeta; IsoId=Q03060-12; Sequence=VSP_025035, VSP_026076, VSP_025037; Note=Produced by alternative promoter usage. Activator; Name=11; Synonyms=CREM-theta1beta, CREM-theta1EFHIbeta; IsoId=Q03060-13; Sequence=VSP_025035, VSP_026076, VSP_000600, VSP_000601; Note=Produced by alternative splicing of isoform 10. Repressor; Name=12; Synonyms=CREM-theta2beta, CREM-theta2EFHIb, CREM-theta2-gamma; IsoId=Q03060-14; Sequence=VSP_025035, VSP_025036, VSP_000600, VSP_000601; Note=Produced by alternative splicing of isoform 5. Repressor; Name=13; Synonyms=CREM-BEFGgammaHIbeta; IsoId=Q03060-15; Sequence=VSP_000599; Note=Produced by alternative splicing of isoform 1. Activator; Name=14; Synonyms=CREM-tau2-gamma, CREM-BEFGHIbeta; IsoId=Q03060-16; Sequence=VSP_000599, VSP_025037; Note=Produced by alternative splicing of isoform 1. Activator; Name=15; Synonyms=CREM-BGHIbeta; IsoId=Q03060-17; Sequence=VSP_000599, VSP_026077, VSP_025037; Note=Produced by alternative splicing of isoform 1. Repressor; Name=16; Synonyms=CREM-deltaC-G, CREM-BgammaHIbeta; IsoId=Q03060-19; Sequence=VSP_000599, VSP_026077, VSP_000600; Note=Produced by alternative splicing of isoform 1. Repressor; Name=17; Synonyms=CREM-BHIbeta; IsoId=Q03060-20; Sequence=VSP_000600, VSP_025037; Note=Produced by alternative splicing of isoform 1. Repressor; Name=18; Synonyms=CREM-BHIalpha; IsoId=Q03060-21; Sequence=VSP_000600, VSP_025037, VSP_025038; Note=Produced by alternative splicing of isoform 1. Repressor; Name=19; Synonyms=CREM-theta1tau2gamma, CREM-theta1EFGgammaHIbeta; IsoId=Q03060-22; Sequence=VSP_025035, VSP_026076; Note=Produced by alternative splicing of isoform 10. Activator; Name=20; IsoId=Q03060-23; Sequence=VSP_025035, VSP_043580, VSP_025038; Note=No experimental confirmation available; Name=22; IsoId=Q03060-25; Sequence=VSP_043782, VSP_000599, VSP_043783, VSP_043784; Note=No experimental confirmation available; Name=21; IsoId=Q03060-24; Sequence=VSP_043713, VSP_043714, VSP_025038; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. PTM: Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. PTM: Stimulated by phosphorylation (By similarity). SIMILARITY: Belongs to the bZIP family. SIMILARITY: Contains 1 bZIP domain. SIMILARITY: Contains 1 KID (kinase-inducible) domain. SEQUENCE CAUTION: Sequence=AAB03751.1; Type=Erroneous termination; Positions=361; Note=Translated as Tyr; Sequence=AAF68266.2; Type=Erroneous gene model prediction; Sequence=CAH72496.1; Type=Erroneous gene model prediction; Sequence=CAH72497.1; Type=Erroneous gene model prediction; Sequence=CAI12138.1; Type=Erroneous gene model prediction; Sequence=CAI12139.1; Type=Erroneous gene model prediction; Sequence=CAI12143.1; Type=Erroneous gene model prediction; GENE SYNONYMS:CREM. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 361 AA; 38940 MW; C1AF0DF57DFB0DAD CRC64;
biopax3:xref	urn:biopax:RelationshipXref:HGNC_HGNC:2352, urn:biopax:RelationshipXref:NCBI GENE_1390, urn:biopax:RelationshipXref:REFSEQ_NP_001872, urn:biopax:RelationshipXref:REFSEQ_NP_853549, urn:biopax:RelationshipXref:REFSEQ_NP_874386, urn:biopax:RelationshipXref:REFSEQ_NP_874387, urn:biopax:RelationshipXref:REFSEQ_NP_874389, urn:biopax:RelationshipXref:REFSEQ_NP_874390, urn:biopax:RelationshipXref:REFSEQ_NP_874392, urn:biopax:RelationshipXref:REFSEQ_NP_874393, urn:biopax:RelationshipXref:REFSEQ_NP_877570, urn:biopax:RelationshipXref:REFSEQ_NP_877571, urn:biopax:RelationshipXref:REFSEQ_NP_877572, urn:biopax:RelationshipXref:REFSEQ_NP_877573, urn:biopax:UnificationXref:UNIPROT_A8K014, urn:biopax:UnificationXref:UNIPROT_A8K3J7, urn:biopax:UnificationXref:UNIPROT_A8K6A1, urn:biopax:UnificationXref:UNIPROT_B4DXC1, urn:biopax:UnificationXref:UNIPROT_O75519, urn:biopax:UnificationXref:UNIPROT_Q03060, urn:biopax:UnificationXref:UNIPROT_Q14503, urn:biopax:UnificationXref:UNIPROT_Q14504, urn:biopax:UnificationXref:UNIPROT_Q14505, urn:biopax:UnificationXref:UNIPROT_Q14506, urn:biopax:UnificationXref:UNIPROT_Q15731, urn:biopax:UnificationXref:UNIPROT_Q16114, urn:biopax:UnificationXref:UNIPROT_Q16116, urn:biopax:UnificationXref:UNIPROT_Q5T9H7, urn:biopax:UnificationXref:UNIPROT_Q5W1A6, urn:biopax:UnificationXref:UNIPROT_Q5W1A8, urn:biopax:UnificationXref:UNIPROT_Q5W1A9, urn:biopax:UnificationXref:UNIPROT_Q5W1B2, urn:biopax:UnificationXref:UNIPROT_Q7Z2Q6, urn:biopax:UnificationXref:UNIPROT_Q8IVD4, urn:biopax:UnificationXref:UNIPROT_Q96AG7, urn:biopax:UnificationXref:UNIPROT_Q9NZ98, urn:biopax:UnificationXref:UNIPROT_Q9NZ99, urn:biopax:UnificationXref:UNIPROT_Q9NZB9
biopax3:displayName	CREM_HUMAN
biopax3:name	CREM, ICER, Inducible cAMP early repressor
biopax3:entityFeature	urn:biopax:ModificationFeature:CREM_HUMAN_1, urn:biopax:ModificationFeature:CREM_HUMAN_2, urn:biopax:ModificationFeature:CREM_HUMAN_3, urn:biopax:ModificationFeature:CREM_HUMAN_4, urn:biopax:ModificationFeature:CREM_HUMAN_5
biopax3:organism	http://identifiers.org/taxonomy/9606
biopax3:sequence	MSKCARKKYIKTNPRQMTMETVESQHDGSITASLTESKSAHVQTQTGQNSIPALAQVSVAGSGTRRGSPAVTLVQLPSGQTIHVQGVIQTPQPWVIQSSEIHTVQVAAIAETDESAESEGVIDSHKRREILSRRPSYRKILNELSSDVPGVPKIEEERSEEEGTPPSIATMAVPTSIYQTSTGQYIAIAQGGTIQISNPGSDGVQGLQALTMTNSGAPPPGATIVQYAAQSADGTQQFFVPGSQVVVQDEETELAPSHMAAATGDMPTYQIRAPTAALPQGVVMAASPGSLHSPQQLAEEATRKRELRLMKNREAAKECRRRKKEYVKCLESRVAVLEVQNKKLIEELETLKDICSPKTDY
biopax3:standardName	cAMP-responsive element modulator