Q02880

FUNCTION: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly ivolved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining of double-stranded DNA. SUBUNIT: Homodimer. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Beta-2; IsoId=Q02880-1; Sequence=Displayed; Name=Beta-1; IsoId=Q02880-2; Sequence=VSP_006532; PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. MISCELLANEOUS: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils. SIMILARITY: Belongs to the type II topoisomerase family. SIMILARITY: Contains 1 Toprim domain. GENE SYNONYMS:TOP2B. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., SEQUENCE 1626 AA; 183267 MW; E60E9262CC68B05D CRC64;

TOP2B_HUMAN

urn:biopax:ModificationFeature:TOP2B_HUMAN_1, urn:biopax:ModificationFeature:TOP2B_HUMAN_10, urn:biopax:ModificationFeature:TOP2B_HUMAN_11, urn:biopax:ModificationFeature:TOP2B_HUMAN_12, urn:biopax:ModificationFeature:TOP2B_HUMAN_13, urn:biopax:ModificationFeature:TOP2B_HUMAN_14, urn:biopax:ModificationFeature:TOP2B_HUMAN_15, urn:biopax:ModificationFeature:TOP2B_HUMAN_16, urn:biopax:ModificationFeature:TOP2B_HUMAN_17, urn:biopax:ModificationFeature:TOP2B_HUMAN_18, urn:biopax:ModificationFeature:TOP2B_HUMAN_19, urn:biopax:ModificationFeature:TOP2B_HUMAN_2, urn:biopax:ModificationFeature:TOP2B_HUMAN_20, urn:biopax:ModificationFeature:TOP2B_HUMAN_21, urn:biopax:ModificationFeature:TOP2B_HUMAN_22, urn:biopax:ModificationFeature:TOP2B_HUMAN_23, urn:biopax:ModificationFeature:TOP2B_HUMAN_24, urn:biopax:ModificationFeature:TOP2B_HUMAN_25, urn:biopax:ModificationFeature:TOP2B_HUMAN_26, urn:biopax:ModificationFeature:TOP2B_HUMAN_27, urn:biopax:ModificationFeature:TOP2B_HUMAN_28, urn:biopax:ModificationFeature:TOP2B_HUMAN_29, urn:biopax:ModificationFeature:TOP2B_HUMAN_3, urn:biopax:ModificationFeature:TOP2B_HUMAN_30, urn:biopax:ModificationFeature:TOP2B_HUMAN_31, urn:biopax:ModificationFeature:TOP2B_HUMAN_32, urn:biopax:ModificationFeature:TOP2B_HUMAN_33, urn:biopax:ModificationFeature:TOP2B_HUMAN_34, urn:biopax:ModificationFeature:TOP2B_HUMAN_35, urn:biopax:ModificationFeature:TOP2B_HUMAN_36, urn:biopax:ModificationFeature:TOP2B_HUMAN_37, urn:biopax:ModificationFeature:TOP2B_HUMAN_4, urn:biopax:ModificationFeature:TOP2B_HUMAN_5, urn:biopax:ModificationFeature:TOP2B_HUMAN_6, urn:biopax:ModificationFeature:TOP2B_HUMAN_7, urn:biopax:ModificationFeature:TOP2B_HUMAN_8, urn:biopax:ModificationFeature:TOP2B_HUMAN_9

MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMFN