| Predicate | Object |
|---|---|
| rdf:type | |
| biopax3:comment |
FUNCTION: RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q01085-1; Sequence=Displayed; Name=2; IsoId=Q01085-2; Sequence=VSP_043700; Note=No experimental confirmation available; PTM: Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA. SIMILARITY: Contains 3 RRM (RNA recognition motif) domains. GENE SYNONYMS:TIAL1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
SEQUENCE 375 AA; 41591 MW; 2F8D1C7169A7817E CRC64;
|
| biopax3:xref |
urn:biopax:RelationshipXref:HGNC_HGNC:11804,
urn:biopax:RelationshipXref:NCBI GENE_7073,
urn:biopax:RelationshipXref:REFSEQ_NP_001029097,
urn:biopax:RelationshipXref:REFSEQ_NP_003243,
urn:biopax:UnificationXref:UNIPROT_A8K3T0,
urn:biopax:UnificationXref:UNIPROT_A8K4L9,
urn:biopax:UnificationXref:UNIPROT_Q01085
|
| biopax3:displayName |
TIAR_HUMAN
|
| biopax3:name |
TIA-1-related protein,
TIAL1
|
| biopax3:entityFeature | |
| biopax3:organism | |
| biopax3:sequence |
MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ
|
| biopax3:standardName |
Nucleolysin TIAR
|